Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550

A -- LAWRENCE LIVERMORE NATIONAL LABORATORY OFFERS FLOW-SORTED, ARRAYED HUMAN CHROMOSOME-SPECIFIC COSMID LIBRARIES FOR SCREENING AND CLONE DISTRIBUTION Announcement The Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy (DOE), is a major partner in the National Laboratory Gene Library Project. The goal of this project was to produce chromosome-specific cosmid libraries and to distribute the clones to the scientific community worldwide. In a chromosome-specific library, the cloned fragments that make up each ``library'' are derived from one of the 24 human chromosome types which were purified by flow-sorting. The cosmid libraries have been arrayed to a depth of at least five-fold as individual clones in 96-well microtiter dishes, each clone having a unique identifier. LLNL has available arrayed cosmid libraries for human chromosomes 1, 3, 7, 9, 12, 18, 21, 22, X, and Y (``Libraries''). We are looking for companies (``Recipients'') who wish to act, on a non-exclusive basis, as resource/distribution centers for screening these arrayed libraries and for distributing individual clones from the library to ``End Users.'' End Users of the clones should be encouraged to make data on the use of clones available to the scientific community by publication and submission of data to appropriate databases. Recipients of the LLNL arrayed cosmid libraries may not rearray the libraries so as to create new clone identifiers, and may not transfer the libraries to any third party without prior written consent by an authorized representative of LLNL. The arrayed libraries will be transferred from LLNL via an Agreement between the Recipient and The Regents of the University of California. The Recipient will be asked to offset the costs of the array replication and transfer (approx. $1,000 - $5,000 per array replica). The Agreement will be coordinated through the LLNL Industrial Partnerships and Commercialization. Recipients should note that no license, either direct or implied, would be granted via this Agreement to the oter University-owned intellectual property. LLNL on behalf of the Federal Government will retain rights to continue research pertinent to the Libraries on behalf of the United States throughout the world. The Regents of the University of California also expressly reserves the right to use the libraries for educational and research purposes. If you are interested in obtaining the arrayed LLNL cosmid libraries, please respond in writing to LLNL providing the following information: (1) The name and address of your organization; (2) the name, address, telephone, and fax of the point of contact in your organization; (3) the expertise and facilities that your organization possesses that would qualify you as a distribution/screening center; and (4) the time frame in which you are willing to accept these libraries. Please send this information to Lawrence Livermore National Laboratory, Industrial Partnerships and Commercialization, Attn: Gene Library Project, L795, P.O. Box 808, Livermore, CA 94550 (FAX No. (510) 423-8988). (023)

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