Contracts Management Branch, National Institute of Neurological Disorders and Stroke, NIH, Federal Building, Room 901, 7550 Wisconsin Avenue, MSC 9190, Bethesda, Maryland 20892-9190

A -- TRANSGENIC RAT MODEL FOR STROKE RESEARCH SOL BAA/RFP No. NIH-NINDS-95-11 due 041795. Point of Contact, Raina Cervantes, 301/496-1813, Contracting Officer, Kirkland Davis, 301/496-9203. The National Institute of Neurological Disorders and Stroke (NINDS), NIH will under a Broad Agency Announcement (BAA)/Request For Proposals (RFP), solicit proposals for developing transgenic rats as an experimental model for the study of cerebral ischemia and stroke in the central nervous system. The term `transgenic rat' is used here broadly to include rats which demonstrate overexpression of genes, deletion of genes (gene knock-out), or alteration in the expression patterns of genes that may be involved in the cellular injury or repair of brain cells within the central nervous system following cerebral ischemia. Independent design and construction of transgenic rats for research concerning the diagnosis, pathophysiology, pathogenesis, treatment and/or prevention of stroke is required. Offerors are required to have existing, appropriate and available transgenic research facilities. Performance of work under this project will involve personnel with established expertise in molecular biology, neurosciences, molecular genetics, and physiology. It is anticipated that two (2) multi-year cost reimbursement type contracts will be awarded for a maximum period of four years each. This is not a Request for Proposals. Request for Proposals (RFP) No. NIH-NINDS-95-11 will be issued on or about February 17, 1995 as a Broad Agency Announcement as defined in FAR 6.102(d)(2) and 35.016. Proposals will be due approximately sixty days after issuance of the BAA/RFP. Written requests for a copy of the BAA/RFP must cite the RFP number referenced above. Please supply this office with two (2) self-addressed mailing labels. All responsible sources may submit a proposal which shall be consideredd by the Government. (025)

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