Environmental Protection Agency, Health Effects Research Laboratory (MD51), Research Triangle Park, VA 27711-0001

A -- BIOLOGICALLY BASED DOSE RESPONSE MODELS FOR DEVELOPMENTAL TOXICITY SOL 1 DUE 030295 POC Contact Point, Barbara Blackwell, (919)541-2886 The U.S. Environmental Protection Agency Office of Health and Environmental Assessment (OHEA) and Health Effects ResearchLaboratory (HERL) is seeking PREPROPOSALS FOR FINANCIAL ASSISTANCE BY COOPERATIVE AGREEMENTS with non-profit or not-for-profit research organizations for research on biologically-based dose-response modelling for developmental toxicity. Such agreements require a minimum of 5% cost sharing by the recipient organization. A high degree of collaboration with the EPA researchers involved in these activities is required (e.g., joint planning and conduct of most tasks and co-authored publications). The proposed project will support the Office of Research and Development's efforts to develop improved health risk assessment procedures. The primary goal of the project is to conduct research aimed at understanding the fundamental mechanisms of abnormal development and developing mathematical models of mechanism-based dose-response relationships in conjunction with EPA bio-modelers and researchers. Potential focal areas include: (1) segmentation disruption; (2) nucleotide pool imbalances; (3) second/third messenger perturbations. Proposals may address one or more of these areas, or entirely independent and novel areas. Proposals addressing concentration-time (CxT) relationships will be given priority for funding. Proposals will be evaluated by expert review panels. The review will be based on the proposer's experience with similar research activities, qualifications of the proposed staff and their understanding of appropriate research approaches and technologies, the relevancy to the mission of OHEA, and the cooperative nature of the proposed working arrangement with EPA staff. The applicant's proposed budget will also be considered in the selection process. EPA's yearly share of the resources for the research area is expected to be $170,000 for each of 3 years, and anticipates making one or two awards. ONLY STATE AND LOCAL GOVERNMENTS, NONPROFIT RESEARCH INSTITUTIONS OF HIGHER EDUCATION, INDIVIDUALS, OR NOT-FOR-PROFIT RESEARCH ORGANIZATIONS THAT ARE ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDER THE FOLLOWING ACTS SHOULD APPLY: Statute authority for these cooperative agreements is found in the Clean Air Act, 42 U.S.C. 7401 04(a)(2). Interested applicants must be eligible to receive Federal Assistance under the Code of Federal Regulations (CFR) Part 30 General Regulations for Assistance Programs, and Part 40-Research and Demonstration Grants. The government reserves the right to not make awards in the research area described in this solicitation. Additional technical instructions and appropriate application materials will be provided upon request. Technical instructions for preparation of preproposals and proposals should be obtained from: Barbara Blackwell, Health Effects Research Laboratory (MD-51), U.S.Environmental Protection Agency, Research Triangle Park, NC 27711; Tel 919-541-2886; Fax 919-541-4324. Responses to this advertisement must be received by close of business (COB) March 31, 1995. Responses should be sent to Barbara Blackwell, Health Effects Research Laboratory (MD-51), U.S. Environmental Protection Agency, Research Triangle Park, NC 27711. (0033)

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