National Cancer Institute, Research Contracts Branch, PCCS, Executive Plaza South, Room 635, Bethesda, MD 20892

A -- THE UNITED KINGDOM INTERNATIONAL TRIAL INTERIM ANALYSIS PROJECT POC Erin C. Lange, Contracting Officer Representative, Susan K. Hoffman, Contracting Officer, 301-496-8603. The National Cancer Institute, Divison of Cancer Prevention and Control, Early Detection Branch intends to enter into negotiations with the United Kingdom. The United Kingdom is conducting a randomized controlled trial to determine whether screening mammography is effective in reducing breast cancer mortality among women 40 - 49 years of age. The purpose of these negotiations is to speed the ascertainment of cancers in the trial populations and ensure the completeness of death information, both in support of an accelerated interim analysis of the trial. The NCI sponsored effort is to provide information which will guide U.S. scientific decisions regarding potential for extending the U.K. trial concept into an international trial with more power to obtain a definitive answer to the question of whether screening women in their forties reduces their risk of dying of breast cancer. Authority: 41 USC 253(c)(1) as set forth in FAR 6.302-1(b)(1). No collect calls will be accepted. See Note(s): 22. (0054)

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