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68 -- SYNTHESIS OF NON-MUTAGENIC DIAMINES FOR POLYMIDES SOL 590410 POC Rita Homady, Contract Specialist, (216) 433-2753, MS 500-306 Paul Karla, Contracting Officer, (216) 433-2824, MS 500-306. The diamine 4,4 - methylenedianiline (MDA) used in the commercial polyimide PMR-15 is known to be mutagenic. The MDA is an intercalating agent that can assume a planar conformation which leads to a frameshift mutagenesis. The objective of this effort is to synthesize at least three new diamines to be used as replacements for MDA in the PMR-15 polyimide resin. The new diamines must be non-mutagenic for both frameshift mutations and base-pair substitutions in the Ames test for mutagenicity. In addition, the structures of the new diamines should have no adverse effect on the thermo-mechanical properties and thermooxidative stability of the PRM-15 polyimide. The second part of this effort involves subjecting the 51 compounds shown in Table I to the Ames test for mutagenicity. Estimated period of performance is 6 months. This notice is for information only. Justification to permit contracting with St. Norbert College has been prepared using citation 10 USC 2304(c)(1) as its authority. See Numbered Note(s): 22. (0062)

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