National Institute of Child Health and Human Development, Office of Grants and Contracts, 6100 Executive Building, Room 7A07, 9000 Rockville Pike, Bethesda, Maryland 20892

A -- LABORATORY TESTS OF BLOOD AND URINE SAMPLES FROM THE CPEP CLINICAL TRIAL. Sol RFP NICHD-DESPR-95-14 due 052295. Contact Lynn Salo, 301-496-4611/Contract Specialist, Harvey Shifrin, 301-496-4611/Contracting Officer. As a part of the Trial of Calcium for Preeclampsia Prevention (CPEP), the National Institute of Child Health and Human Development (NICHD) is planning 1) to compare urinary excretion of calcium and related nutrients in preeclamptic women before and after the diagnosis of preeclampsia to that in normal pregnant women at comparable gestational ages, and to determine the effect of oral calcium supplementation on the excretion of these substances; 2) to determine the presence or absence of proteinuria not previously ascertained in up to 125 urine specimens obtained from normal women and from women with gestational hypertension within 7 days of documented hypertension; and 3) to measure the quantity of elemental calcium in each of up to 100 study medication tablets for purposes of quality control. The comparison of urinary excretion of calcium and related nutrients will be a nested case control study using stored urine specimens collected at specified times during pregnancy and at the diagnosis of preeclampsia from pregnant women participating in CPEP. CPEP is a randomized clinical trial designed to determine whether oral calcium supplementation will prevent preeclampsia. The Contractor will be expected to measure calcium, sodium, potassium, chloride, magnesium, zinc, phosphorus, urea nitrogen, and creatinine in approximately 5912 urine specimens selected by the Project Officer over the course of one year. Measurements of protein and creatinine in up to 125 additional urine specimens and calcium content of up to 100 study medication tablets must also be completed within the same year. This announcement is a new solicitation. The issueance of the RFP will be on or about March 22, 1995, and proposals are due by 4:00 p.m. (local time), May 19, 1995. The short-form version of the RFP will be provided first, which includes only the Statement of Work, Technical Reporting Requirements, Background Information, and the Evaluation Criteria to be used for selection of the awardee. After examining this, a full-text version of the RFP must be requested, in writing, for those organizations interested in responding. Those organizations desiring a copy of the above short-form RFP may send their written request to Mrs. Lynn Salo at the address listed above. Fax requests are acceptable (301-496-3676). All requests must cite the RFP number above and include two self-addressed mailing labels. All sources who consider themselves qualified are encouraged to submit a proposal. This advertisement does not commit the Government to make an award. (062)

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