HSC/PKR DCS Contracting, Bldg 626, Brooks AFB TX 78235-5353

A -- PROFESSIONAL TOXICOLOGY RESEARCH SERVICES POC MS LEE BALES, CONTRACT NEGOTIATOR, (210) 536-6397, MR MICHAEL FLEISCHMAN, CONTRACTING OFFICER. Toxicology Research - SSS PKR 95-04. Qualified sources are being sought for professional toxicology services in support of the Toxicology Division, Armstrong Laboratory, Wright-Patterson AFB, OH, which conducts a broad spectrum of scientific research designed to quantitate safe exposure levels for chemicals. The successful offeror will be teaming with the Army, Navy, and Air Force (triservice) to design and perform research to assess pharmacokinetics, local and systemic effects, and mechanisms of toxicity for chemicals chosen by the tri-service. Acquiring information about the deleterious interaction of chemicals with living organisms requires a step-wise application of specific scientific processes to gather data. The information obtained is used either to answer the questions posed or to design the experiments necessary to generate those answers. The research efforts will include descriptive/general toxicology, mechanistic toxicology (toxicokinetics, mechanism of action and toxicodynamics), and predictive toxicology (parameter determination, model development and model validation). Studies will range from short-term pharmacokinetic investigations to lifetime carcinogenic bioassays and will include oral, inhalation, and dermal exposures. Development and application of computer modeling techniques and alternatives, such as invitro screening (cell culture, liver slice, etc.), will be necessary to provide an accurate and responsive chemical hazard assessment capability. Post-doctoral level experience in the areas of toxicology, pharmacology, physiology, pharmacokinetics, physiologically-based modeling, analytical chemistry, biochemistry and inhalation/aerosal engineering is required to advance the state-of-the-art. Research support functions that are anticipated include safety/quality assurance, logistics, archives, fabrication, tech editing, computer system management and related technical areas to support the scientific staff in accomplishing the objectives of the research projects. A cost-reimbursement contract is contemplated for this effort with an anticipated baseline level of effort at 87,000 hrs/yr. Additional level of effort, generally short term, may be required to support unforeseen surges in project workload (up to 27,000 hrs/yr). The period of performance is contemplated to be 60 months. A Security Clearance WILL NOT be required in performance of this work. This announcement IS NOT A REQUEST FOR PROPOSAL or ANNOUNCEMENT OF SOLICITATION. Only responses that provide the requested information applicable to your firm will be considered. SIC Code 8731 has been assigned. Firms should indicate whether they are a small business, small disadvantaged business, woman-owned business or small business 8(a). The general definitions to be used to determine whether your firm is a small or small disadvantaged business are as follows: ''A small business concern is a concern that is independently owned and operated, is not dominant in the field of operation in which it is bidding on Government contract, and with its affiliates the number of employees does not exceed 500 persons.'' '''Concerns' means any business entity organized for profit with a place of business located in the United States, including but not limited to an individual, partnership, corporation, joint ventures, association, or cooperation.'' ''A small disadvantaged business is a concern that is at least 51 percent unconditionally owned by one or more individuals who are both socially and economically disadvantaged, or a publicly owned business that has at least 51 percent of its stock unconditionally owned by one or more socially and economically disadvantaged individuals and that has its management and daily business controlled by one or more such individuals.'' The Air Force reserves the right to consider a small business set-aside based on responses hereto. All respondees to this synopsis shall include their assigned Commercial and Government Entity (CAGE) Code (i.e., Federal Supply Code for Mfrs., a five digit code assigned by Cmdr, Def Logisitics Service Center, Attn: DECS-CGD, Federal Center, Battle Creek MI., Ref DOD 5000.12(M). Small businesses interested in this effort MUST respond with a complete capability/qualification package describing the company's technical expertise and experience, personnel and facilities and motivation for participating in this program. SEE READERS GUIDE NOTE(S) ITEM NUMBER 25 FOR FURTHER DETAILS. Large businesses need only reply with a letter of interest. Responses submitted should be in one copy only. Each response shoud reference SSS PKr 95-04. Responses should be sent to: HSC/PKRE, 8005 9th St, ATTN: Ms Lee Bales, Brooks AFB TX 78235-5353. Any non-technical and/or contractual questions should be referred to Ms Lee Bales, (210) 536-6397. Technical questions may be directed to Lt Col Terry Childress, AL/OET, Wright-Patterson AFB, OH (513) 255-3423. An Ombudsman has been appointed to hear concerns from offerors or potential offerors during the proposal development phase of this acquisition. The purpose of the Ombudsman is not to diminish the authority of the program director or Contracting Officer, but to communicate contractor concerns, issues, disagreements, and recommendations to the appropriate government personnel. When requested, the Ombudsman will maintain strict confidentiality as to the source of the concern. The Ombudsman does not participate in the evaluation of proposals or in the source selection process. Interested parties are invited to contact Mr Emile Baladi, HSC/XRY, 2510 Kennedy Dr, Suite 1, Brooks AFB TX 78235-5120 or call (210) 536-2903. Closing date for submission of responses is thirty days from publication of this notice. (0065)

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