The NATIONAL INSTITUTES OF HEALTH, DHHS, OD, DEA, AMB, SSAS The NATCHER BUILDING 45 CENTER DRIVE MSC 6600, ROOM 6AN32 Bethesda, MARYLAND 20892-6600

66 -- 66-DELTA S SYSTEM ISOTOPE RATION MASS SPECTROMETER INCLUDING DUAL VISCOUS INLET SYSTEM, MEMCO, HD COLLECTOR & THREE (3) YEAR WARRANTY SOL NIH-NIDDK-95-7 DUE 041595 POC Livie V. Spearman, III., CONTRACT SPECIALIST, (301) 594 - 8855. The NATIONAL INSTITUTES OF HEALTH (NIH), THE NATIONAL INSTITUTE Of DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) intends to contract on a sole source basis with FINNIGAN MAT 355 RIVER OAKS PARKWAY SAN JOSE, CA 95134 for the DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING DUAL VISCOUS Inlet SYSTEM, MEMCO S, HD COLLETOR & A THREE (3) YEAR WARRANTY. FINNIGAN MAT, INC., holds all rights on distribution. The research goals of the CLINICAL DIABETES & NUTRITION SECTION include studies aimed at understanding energy expenditure as a factor in the development of obesity and diabetes in the PIMA INDIAN POPULATION. Previous research, which documented energy expenditure in a respiratory chamber, now is being extended to free-living conditions. The DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING Dual VISCOUS INLET SYSTEM, MEMCO S, HD COLLECTOR is an essential and critical item in that research. To significantly enhance the performance of the current ISOTOPE RATIO FINNIGAN MAT 251 EQUIPMENT, to enable a two-fold increase in productivity of the lab and to enable additional studies of substrate oxidation, it is requested that the capability of the lab be upgraded through the purchase of another mass spectrometer, i.e., a DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING DUAL VISCOUS INLET SYSTEM, MEMCO S, & HD COLLECTORS. The availability of the second mass spectrometer would eliminate current lengthy waiting periods for the results of the program's studies of ENERGY EXPENDITURE In FREE-LIVING CONDITIONS, ''ENERGY EXPENDITURE IN PIMA INDIANS: RISK FACTORS FOR BODY WEIGHT GAIN,''. The DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING Dual VISCOUS INLET SYSTEM, MEMCO S, HD COLLECTORS will be used to run hydrogen sample determination. Whereas, The FINNIGAN MAT 251 will be dedicated to measure CO2 enrichment. Consequently, isotopic enrichment measurements productivity will be doubled. The NIH believes the proposed contractor is the only source available as it is uniquely qualified to provide the subject instrument. The DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING Dual VISCOUS INLET SYSTEM, MEMCO S, HD COLLECTOR must be fully hardware and software compatible with the existing FINNIGAN MAT ISOTOPE RATIO MAT 251 METER peripherals currently used in the laboratory, i.e., the CO2 EQUILIBRATOR AND THE HYDROGEN EQUILIBRATOR, as well as THE MULTIPORT supported by the FINNIGAN MAT software currently running the ISOTOPE RATIO FINNIGAN MAT 251 SPECTROMETER SYSTEM. These expensive peripherals were custom designed for the laboratory to be compatible with THE ISOTOPE RATIO FINNIGAN MAT 251 SYSTEM to measure ratios of the stable isotopes of 18 O TO 16 O and DEUTERIUM TO HYDROGEN. Therefore, the laboratory could nearly double production by having another mass spectrometer, i.e., The DELTA S SYSTEM ISOTOPE RATIO MASS SPECTROMETER INCLUDING Dual VISCOUS INLET SYSTEM, MEMCO S, & HD COLLECTORS. This permits a doubling of the productivity for the studies of energy expenditure. To date, there is no other comparable instrument available. This is not a formal solicitation requests, however concerns that respond should furnish detailed data concerning their capabilities demonstrating the offeror ability to provide the equipment needed. THIS NOTICE MAY REPRESENT THE ONLY OFFICIAL NOTICE Of SUCH A SOLICITATION (SEE Note 22). See Numbered Note(s): 22. (0066)

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