National Institute of Standards and Technology, Acquisition and Assistance Division, Building 301, Room Bll7, Gaithersburg, MD 20899

70 -- BIOMOLECULAR SIMULATION SOFTWARE PACKAGE SOL 52SBNB5C8699 DUE 050895 POC Kathleen Lettofsky (301) 975-6342/C.O.: Ruth Ann Maris The National Institute of Standards and Technology (NIST) intends to negotiate on a sole source basis under the authority of 41 USC 253(c)(1). NIST has a requirement, which includes the theoretical simulation and the experimental spectroscopic investigation of macromolecules in both the solution and solid state. The computation needs of this program require an integrated suite of software modules that can be used for (a) nuclear magnetic resonance spectral analysis and macromolecular structure determination, including distance geometry, the iterative relaxation matrix approach, nuclear Overhauser effect back calculation, and simulated annealing; (b) molecular orbital, mechanics, and dynamics computations, and (c) quantum mechanical calculations on macromolecules in the solution and solid state. Also required, is a seamless transfer of spectral data, spatial data and parameters, and quantum mechanical data and results between the different software modules, which must, therefore, be compatible with each other. The government's requirement of the particular combination of solids and solution state software modules is only available from Biosym Technologies, Parsipanny, NJ. The purchase of a Biomolecular Simulation Software package consists of the following modules: 1) Insight II; 2) Discover; 3) Biopolymer; 4) DelPhi; 5) Homology; 6) Sketcher; 7) Search/Compare; 8) Decipher; 9) Consensus; 10) Profiles-3D; 11) Felix-Assign; 12) Felix-Model; 13) NMR Refine DGII; 14) DMol/DSolid; 15) Turbomole; 16) Zindo; 17) Solids; 18) Solids Adjustment; 19) Solids Embed; 20) Solids Docking; 21) Plane Wave; 22) ESOCS; and 23) NMR Refine Advance Builder. Delivery is required Freight on Board (FOB) destination, Gaithersburg, MD within 30 days. Interested offerors may identify their interest and capability to respond to the requirements by submitting a capability statement. The capability statement must provide adequate information and qualifications to provide this type of software package. All of the above must be received for the Government to consider whether to open this requirement for competition. This notice of intent is not a requirement for competitive proposals. However, all ''capability statements'' received within 45 days after date of preparation of this synopsis will be considered by the Government. A solicitation is not available. See Numbered Note 22. (0082)

Loren Data Corp. http://www.ld.com (SYN# 0395 19950324\70-0004.SOL)