National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Research Commons Building, P.O. Box 12874, Research Triangle Park, NC 27709

A -- SOLE SOURCE ADDITIONAL WORK EXTENSION FOR CONTRACT NO. N01-ES-25354 ENTITLED ''PATERNALLY MEDIATED EFFECTS ON REPRODUCTION'' POC Contact Vondia C. Malone, Contract Specialist, (919) 541-0428; Phillip D. Jones, Contracting Officer, (919) 541-0426 The National Institute of Environmental Health Sciences (NIEHS) intends to negotiate with the University of Bristol, England as a sole source for a 20-monthextension to existing contract number N01-ES-25354 to investigate environmental pollution and child development in the first three years of life, building on the AvonLongitudinal Study of Pregnancies and Children (ALSPAC). The contract as currentlywritten provides the English ELSPAC (European component) data on exposure of thefetus and infant to various toxicants, and provides for the collection of data from theALSPAC study. Preliminary analyses of the data collected by the ALSPAC study indicated that change in the sleeping position of infants during the first six months of lifewas accompanied by a reduction in ear infections and a reduction in the proportion ofsix-month old children suspected of having a hearing problem. Because the childrenare growing older, it is important to obtain hearing measurements as soon as possibleto allow for collection of these data prior to the children's aging out of the appropriateage range for measurement of hearing and correlation to earlier data. Authority: 41USC 253(c)(1), as set forth in FAR 6.302-1. Inherent duplication of cost to theGovernment and unacceptable delays in completing the project makes competition unfeasible for this work. See Numbered Note 22. (0110)

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