National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, P.O. Box 12874, 4401 Building, Research Commons, Research Triangle Park, NC 27709

A -- IDENTIFICATION OF HEREDITARY PROSTATE CANCER GENE BASED ON FINNISH FAMILIES SOL NIH-ES-95-29 POC Contact Velvet M. Torain, Contract Specialist, 919/541-0400; Phillip D. Jones, Contracting Officer, 919/541-0426 The National Institute of Environmental Health Sciences intends to negotiate a contract with Tampere University, Tampere Finland, to explore the genetics of hereditary prostate cancer (HPC) by: 1) determining the yield of potential participants with HPC or related HPC affected Finnish men; 2) finding out how many of those identified in the data base search are available for sampling and willing to participate; 3) collecting blood specimens from participants in order to extract DNA for shipment to the National Center for Human Genome Research for linkage disequilibrium analyses and other tests; and 4) determining genetic changes in sporadic and hereditary prostate cancer. Authority: 41 USC 253(c)(1), as set forth in FAR 6.302-1. The Finnish population is uniquely suited for studies of the genetics of prostate cancer because Finland has developed a comprehensive and complete central databases on the medical characteristics of its population. Tampere University has extensive experience in prostate cancer research, and has many previous joint studies with the Finnish Cancer Registry and will be able to utilize those contacts to effectively trace patients with family history. Tampere University also has a computer database of virtually all prostate cancer cases from the years 1977 to 1992. Inherent duplication of cost to the Government and unacceptable delays associated with initiating a new study to obtain data that already exist makes competition unfeasible for the above described work. See Numbered Note 22. (0116)

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