National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Building, P.O. Box 12874, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE POTENTIAL OF 50/60 HZ MAGNETIC FIELDS TO PROMOTE BREAST CANCER IN DMBA-TREATED FEMALE SPRAGUE DAWLEY RATS FOR THE NATIONAL TOXICOLOGY PROGRAM (NTP) SOL NIH-ES-95-31 DUE 070495 POC Contact Jo Ann Lewis, Contract Specialist, (919) 541-7893 The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposalsfor studies designed to evaluate the potential of 50 Hz magnetic fields to promote mammarygland carcinogenesis in Sprague Dawley rats initiated with dimethylbenzanthracene (DMBA).The purpose of the 13-week study will be to replicate, as nearly as possible, the series ofstudies reported by Loscher, that 50 Hz magnetic fields have the potential to increasethe breast cancer rate in DMBA-treated female Sprague Dawley rats. This study will involvethe conduct of 13-week initiation/promotion studies in which animals will be exposed to 4weekly intragastric doses of 5 mg/animal of DMBA and to magnetic fields of specifiedintensities and frequencies. The purpose of the 26-week study will be to determine whether 50or 60 Hz magnetic fields can promote cancer in a standard DMBA model. The animals willbe exposed to one intragastric exposure of 10 mg per animal of DMBA followed by exposuresto 50 and 60 Hz magnetic fields of specified intensities for 26 weeks. This project may havethree options: a 13-week study, a 26-week study, and a combination study where the 13- and26-week studies are run concurrently. This project will be separated in two phases. Phase 1will be the development phase which will comprise of activities associated with theprocurement of equipment and materials for the construction/renovation of the exposure andmonitoring systems and the development effort needed to determine that the system functionsappropriately. Phase 2 will be the initiation/promotion studies where one of the three optionswill be exercised. The Government estimates that Phase 1 will require approximately 1.04professional person-years per contract year and 0.24 technical person-years per contract year.Phase 2 will require approximately 1.9 professional person years and 3.4 technical personyears for the 13-week study and 2.9 professional person-years and 5.5 technical person-yearsfor the 26-week study. The estimated period of performance is 17 months. Requests mustreference RFP No. NIH-ES-95-31 and must be directed to the office listed above. Allresponsible sources may submit a proposal which shall be considered by the Agency.(0121)

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