National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Station Support Section, 45 Center Drive MSC 6600, Room 6AN32, Bethesda, Maryland 20892

70 -- REACCA DATABASE UPDATES AND MAINTENANCE SOL NIH-NIDDK-95-13 DUE 071795 POC Katrina James, Contracts Specialist, 301-594-7730. The National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) intends to contract on a sole source basis with Molecular Design Limited Information Systems, Inc., Westchester, Illinois for REACCS Database Updates and Maintenance for REACCS software. The software include REACCS for OpenVMS VAX, Theilheimer, ACDRX, REACCS-JSM, ORGSYN and Reference Library of Synthetic Methodology. In a design of experimental procedures in synthetic chemistry, chemists rely heavilyon previous knowledge and experience published in the literature. Experimental conditions are desinged based on both the chemist's own experience and knowledge and on finding proceudres that have been used previously for similar, not necessarily identical, procedures. The enormous expansion of the volume of available literature provides the scientist with an ever-increasing pool of information from which to design experiments, but, at the same time, introduces serious challenges as to how to access this literature. Fortunately, computerized searching has met many of these challenges. REACCS is particularly useful in that, using the graphics part of the software, the chemist need only draw the reaction, or half-reaction, of interest. A variety of search options then rapidly gives access to published material that relate to this problem. Older literature, as well as periodically up-dated new literature, is available for searching. Using REACCS, the chemist can do in minutes what otherwise would require days of manual library searching. Since we first installed REACCS in 1988, there has been a growing reliance on this software by an increasing number of NIH scientists. The REACCS system has proven to be extremely vital to the operation of this laboratory and to other laboratories at NIH in the design of reaction sequences. The system must run on an IBM/V or VAS/VAX operataing system; must be available for in-house use on NIH computers; must display structures graphically and allow input and query construction using mouse, light pen or other input device by drawing structures on the screen of a graphics terminal; the system must have databases of at least 75,000 reactions available for use with the program. Database must include reactions published before 1970; the system must have documentation and training programs available. The NIH believes the proposed contractor is the only source available as it is uniquely qualified to the provide the subject REACCS Database Updates and Maintenance. This is not a formal solicitation. However, concerns that respond should furnish detailed data concerning their compabilities demonstrating the offeror ability to provide the equipment needed. Determination to use Other Than Full and Open Competition was made in accordance with 41 USC 253 (c)(1) as set forth in FAR 6.302-1. This notice any represent the only official notice of such a solicitation. DPA approval is pending. Note 22. (0150)

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