National Cancer Institute, Research Contracts Branch, Purchasing and Support Contracts Section, EPS/638, 6120 EXECUTIVE BLVD MSC 7228, BETHESDA MD 20892-7228

66 -- FURNISH AND INSTALL A BIACORE 2000 SOL N02-CB-56244-81 POC Janet Mattson, Contracting Officer, 301/402-4509. The National Cancer Institute, Laboratory of Biochemistry, plans to procure on a SOLE SOURCE BASIS, under authority of FAR 6.302-1, in accordance with 41 U.S.C. 253 (c)(1), a BIOcore 2000, which will be furnished and installed by Pharmacia Biosensor, 800 Central Avenue, P.O. Box 1327 Piscataway, NJ 08855. The NCI requires the use of the BIAcore 2000's plasmon resonance to detect biomolecular interactions in real time, providing information concerning the binding and dissociation of two or more molecules such as protein-protein, receptor-ligand, protein-nucleic acid, drug-protein, and nucleic acid- nucleic acid configurations. Minimal functional performance characteristics are as follows: (1) shall use surface plasmon resonance to detect and continuously monitor molecular interactions simultaneously in up to 4 flow cells in real-time, label free, (2) shall be fully automated for sample handling and shall include sample recovery and fraction collection, and (3) shall be capable of detecting low molecular weight molecules in a wide range of temperatures. It is the Government's belief that the above specifications can only be met by Pharmacia Biosensor. This notice of intent is not a request for competitive proposals, however, interested parties may identify their interest and capability to respond to the requirement. Information furnished shall include enough material, in sufficient detail, to perform a proper evaluation of their ability to perform. Closing date is 45 days after publication of this notice. SEE Note 22. (0153)

Loren Data Corp. http://www.ld.com (SYN# 0275 19950605\66-0003.SOL)