DHHS/National Institute on Alcohol Abuse and Alcoholism, Contracts Management Branch, Willco Building, Suite 504, 6000 Executive Boulevard, MSC 7003, Bethesda, Maryland 20892-7003

A -- TOXICOLOGY STUDIES SOL AA-95-08 DUE 073195 POC C. Timothy Crilley, Contract Specialist, 301-443-1191, Roberta S. Wilhelm, Contracting Officer, 301-443-1191 This proposed contract is 100% set-aside for small business concerns, under SIC Code 8731, with a size standard of 500 employees or less. The National Institute on Alcohol Abuse and Alcoholism requires two (2) repeated dose acute toxicity studies, one of MDL-100-907 and the other of WYE-100-635, each to be conducted in mice and rabbits. Prospective offerors shall submit their proposals in accordance with the following minimum requirements. Offerors shall furnish test animals, provide husbandry and all services for toxicology studies in mice and rabbits. Mice shall be strain CD-1, male and female (females nulliparous and non-pregnant), age (at study initiation) 4-6 weeks, 5 weeks preferred. Rabbits shall be strain New Zealand white, male and female (females nulliparous and non-pregnant), adult, 6 months of age. Offerors shall be a recognized laboratory with expertise in repeated dose acute toxicology pathology studies. Offerors shall have a thorough knowledge of the FDA requirements and GLP regulations for preclinical animal toxicology/pathology tests that are requisite for human use for new diagnostic drugs. Offerors shall be a USDA registered facility, and have or obtain prior to contract award, an approved assurance statement on file with OPRR, NIH. The Government contemplates awarding a four month contract as a result of this solicitation. The Government reserves the right to award two separate contracts resulting from this solicitation. The anticipated start date of the new contract is September 29, 1995. Requests for solicitation documents must be in writing or via facsmilie, telephone requests will not be honored. Our facsimile number is (301) 443-3891. All responsible concerns may submit an offer which will be considered by this agency. (0159)

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