National Institutes of Health, Office of Purchasing and Contracts, CC 6006 Executive Blvd., Suite 311 Bethesda, MD 20892-7058

66 -- CAPILLARY ELECTROPHORESIS INSTRUMENT SOL CC-95-08 POC Ann Argaman, Contract Specialist, or Patrick Williams, Contracting Officer (301)496-3704. This is a Notice of Intent that The National Institutes of Health under the authority of 41 USC(c)(1) intends to negotiate and award a sole source contract to Beckman Instruments, Inc. to provide and install a capillary electrophoresis instrument as well as training on the use of the instrument. The instrument must meet the following minimum requirements: Be capable of determining the active ingredients in a formulation; separate and quantiate enantiomer of chiral drug substances and drug products; able to detect and determine drug related impurities as low as 0.1%; the equipment design must be modular to allow detection by diode array, filtered UV, and laser induced fluorescence for high sensitivity work. In addition, it must have the option of an additional bi-polar power supply for a direct interface into various mass spectometry systems; liquid or comparable cooling system of the capillary is required over a range of up to 50 degrees centigrade. Retention time and quantitative accuracy must be reproducible to better than 1% relative standard deviation (R.S.D.). Temperature selection shall be programmable to 0.1% degree centigrade increments; must be capable of carrying out analysis using sample volumes as low as 5 microliters; must have an autosampler capable of handling at least 20 samples and able to link runs in sequence. The software must include vial identification as to location and content; must allow computer controlled isotachophoresis and isoelectric focusing; must include system suitability for direct calculations of efficiencies, resolution and other defined criteria. One to two days of general training on the use of the equipment for Government personnel is required when the instrument is installed. A second more detailed training session of between 3 to 5 work days in duration given to 3 Government employees prior to final Government acceptance of the equipment is also required. This training shall include a general discussion on the principles and theory of the electrophoresis process; a brief discussion of the principles and theory of operation; an in depth discussion on the operation procedures covering areas such as recognition of faults and resetting alarms; a maintenance portion dealing with component identification and maintenance, adjustment and calibration procedures, use of the maintenance manuals, troubleshooting, replacement of parts, and life expectancy, etc. All responses must be written and received within 45 calendar days from the published date of this notice. Oral communication is not acceptable and will not be honored. A statement of Work is available upon request. Responses requesting the solicitation without providing the required documentation shall not be considered. There is no solicitation document. Concerns that respond to this notice will be considered only if furnishing clear and convincing documentation demonstrating their ability to meet, at a minimum the stated requirements. Written responses should contain sufficient technical information and a description of the proposed system to be supplied which meets the requirements in order to permit agency analysis to establish a bonafide capability to meet the stated requirements and should be directed to Ann Argaman at the address above. A determination by the Government to open the requirement to competition based upon responses to this notice is solely within the discretion of the Government. The Government will not pay for preparation or submission of any information submitted in response to this synopsis. See Numbered Note(s): 22. (0163)

Loren Data Corp. http://www.ld.com (SYN# 0447 19950613\66-0002.SOL)