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A -- NON-HUMAN PRIMATE MODELS OF AIDS FOR EVAULATING THERAPIES SOL NIAID-DAIDS-96-15 DUE 101295 POC Joyce Sagami, Contract Specialist 301-496-7118. The Targeted Interventions Branch, Basic Sciences Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institute of Health, has a requirement for evaluating therapeutic approaches and drug-based inhibitors of sexual transmission for HIV/AIDS in non-human primate models of lentivirus infection. Evaluation encompasses the determination of efficacy and toxicity, and when needed, limited pharmacokinetics in models of (i) acute and chronic infection and (ii) sexual transmission. Therapies to be tested, alone and in combination, include antiviral agents (drugs and biologics), immune-based strategies, and gene-based therapies. Examples of lentivirus models appropriate for this RFP include HIV-1, HIV-2, pathogenic SHIV, or other relevant lentivirus that induces disease in a non-human primate animal model. Excluded from this competition are small animal models of lentivirus infection. These capabilities will be used by the Division of AIDS, NIAID, in its efforts to develop intervention and prevention strategies for HIV/AIDS. It is anticipated that two (2) cost reimbursement, level-of-effort type contracts will be awarded for a period of five (5) years. However, the Government reserves the right to limit the number of awards based on the merit of the technical proposals received. The electronic version of RFP-NIH-NIAID-DAIDS-96-15 will be available on or about June 30, 1995, through the NIH Gopher and Internet using the following elecronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOVPORT 70 (you should now be in the NIH Gopher). Select ''Grant and Research Information'', then select ''R&D Request for Proposals (RFP). 2) To access the NIH Grant Line (Internet): Configure your terminal emulator as: 1200 or 2400 baud, even parity, 7 data bits, 1 stop bit, Half Duplex. Using the procedure specified in your communication software, dial 301-402-2221. When you get a response indicating that you have been connected, then type, GEN1 (the comma is mandatory) and press ENTER; you will be prompted by NIH system for ''INITIALS?''. Type BB5 and press ENTER. You will then be prompted for ''Account?''. Type CCS2 and press ENTER. Please note that the RFP for this procurement has been revised to include only the Statement of Work, deliverable and reporting requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on or about October 12, 1995. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit he Government to award a contract. Point of Contact: Joyce Sagami, Contract Specialist, Electronic mail address: JS73b@nih.gov Telephone: (301) 402-7118, Fax: (301) 402-0972. No collect calls will be accepted. (0163)

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