NATIONAL INSTITUTES OF HEALTH, NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES (NIDDK) NATCHER BUILDING, ROOM 6AN32 45 CENTER DRIVE MSC 6600 BETHESDA, MARYLAND 20892-6600

66 -- 66-LASERSHARP, 24 BIT SOFTWARE UPGRADE FOR MRC-1000, COMPAQ PROSIGNA PENTIUM COMPUTER NEC-XE 21'' INCH HIGH RESOLUTION MONITOR SOL NIH-NIDDK-95-108 DUE 081495 POC LIVIE V. SPEARMAN, III., CONTRACT SPECIALIST (301) 594-8855. The National Institutes Of Health (NIH), National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) intends to purchase through a Request For Quotation (RFQ) The Lasersharp 24 Bit Software/Hardware Upgrade, a Three (3) Dimensional Software Package for The Bio-Rad Medical Research Council (MRC)-1000 Confocal Laser Imaging System Upgrade. The Bio-Rad Medical Research Council (MRC)-1000 Confocal Laser Imaging System Upgrade updates our existing Bio-Rad 600 Confocal Imaging System which is used for image analysis of biological speciamens with fluorescence microscopy. The Lasersharp 24 Bit Software/Hardware Upgrade will convert this analog system into an entirely digital system, significantly increasing the resolution of the images that will be produced and collecting data from biological material. The Lasersharp 24 Bit Software/Hardware Upgrade will also provide integrated three-dimensional rendering capacity that allows analysis of data using parameters not presently available to us. THE SOFTWARE MUST PROVIDE THE FOLLOWING MANDATORY CAPABILITIES: 1) Twenty-Four (24) -Bit Image Acquisition From A Bio-Rad 1000 Confocal Scanhead, 2) Integrated Three (3) Dimensional Rendering. THE HARDWARE MUST BE UPGRADED TO THE FOLLOWING MINIMUM MANDATORY SPECIFICATIONS: 1) Ninety (90) MHz Pentium Computer 2) 1050 MB Hard Drive (SCSI-2) 3) Thirty-Two (32) MB RAM 4) CD-ROM 5) 1.44 MB 3.5 Inch Floppy Drive 6) Twenty-One (21) Inch High-Resolution Monitor With 1280 x 1024 Pixel Array 7) Data Acquisition Board 8) Custom High Resolution Display Card The Institute intends to purchase this equipment by Other Than Full And Open Competition. The hardware must be completely integrated with the existing Confocal Laser Scanhead and its High Sensitivity Photomultipliers. The intended source Bio-Rad Laboratories is the manufacture of the Lasersharp 24 Bit Software/Hardware Upgrade and customized display card, and also the vendor for upgraded computer and monitor. Bio-Rad Laboratories guarantees complete of standard software and hardware into the existing Bio-Rad Laboratories current systems, for those elements that they provide. All responsibile sources may submit a Request For Quotation, which if timely received, shall be considered by the agency. (See Note 22). It is anticipated that Request For Quotation (RFQ) Number NIDDK-SSAS-95-108, will be available fifteen (15) days after the publication date of this synopsis. Receipt of quotations will be due ten (10) days after the release of the RFQ. The anticipated award date is August 14, 1995. Requests for copies of the RFQ must be in writing and may be requested by FAX (301) 480-4226. Quotations must be submitted in writing to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) The Natcher Building, Room 6AN32 45 Center Drive MSC 6600 Bethesda, Maryland 20892-6600 Attention Livie V. Spearman, III. FAX quotations will only be accepted if dated and signed by an authorized company representation. (0201)

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