|
COMMERCE BUSINESS DAILY ISSUE OF AUGUST 28,1995 PSA#1419Contracts Management Branch, NICHD, National Institutes of Health,
Executive Building, Suite 7A-07, 6100 Executive Blvd., MSC 7510,
Bethesda, Maryland 20892-7510 A -- MAINTENANCE AND OPERATION OF A SYNTHETIC CHEMICAL FACILITY SOL
RFP-NICHD-CD-95-19 due 110895. Contact Karlene Ruddy, Contract
Specialist, 301-496-4611. The Contraceptive Development Branch of the
Center for Population Research, NICHD, has a requirement for the
maintenance and operation of a synthetic chemical facility for the
synthesis of anti-fertility agents on a laboratory scale (1-5 grams) as
well as on a relatively large scale (1,000 grams). The maximum
quantities of any final product to be prepared by multistep synthesis
via batchwise operations will not normally exceed 1000 grams. It is
desirable that Offerors have expertise in the synthesis of a variety of
optically active steroids, steroid-protein conjugates as immunogenic
agents for radioimmunoassay as well as their tracers to be
radiolabelled with 3H and 125I, a wide variety of unnatural amino acids
including resolutionwork, stereoselective synthesis, and determination
of their optical purity, radiolabelled compounds for metabolism
studies, heterocyclic, carbocyclic and other non-steroidal compounds
which may be of significance to the contraceptive development program.
In addition, the capability to perform High Performance Liquid
Chromatograhy (HPLC) analysis for the detection and quantification of
circulating drugs in serum, urine and feces from animals, and to
perform analytical work in order to access the purity of compounds, is
also desirable. Specific assignment of compounds and quantities to be
prepared will be determined by the Project Officer. Major emphasis
will be on the preparation of experimental compounts on a laboratory
scale (1-5 grams). As minimum requirements, organizations must have the
following in-house equipment (or indications of anticipated purchase of
same): Ultraviolet, infrared and 1Hand 13C nuclear magnetic resonance
spectrometers (90-100 MHZ), mass spectrometer, polarimeter, gas
chromatography, analytical high performance liquid chromatography
preferably equipped with an integrator and preparative high performance
liquid chromatography which can provide gram quantities of purified
compounds. The Government does not intend to furnish any of the above
equipment or facilities. The offeror's facilities must meet
requirements for current Good Manufactuing Practices (cGMP) and must
meet requirements in compliance with OSHA for protection of its
workers. The offeror must have (1) a nuclear license to handle
radioactive materials and (2) a controlled substance license to handle
androgens. The offeror must have in-house capabilities for a
relatively large scale synthesis and FIVE (5) FULL TIME SUPPORTING
TECHNICAL STAFF (CHEMISTS PREFERABLY WITH a B.S. or M.S. DEGREE) who
will devote 100% of their time to the project. NO SUBCONTRACTING will
be permitted. The above minimum requirements must be met at time of
proposal submission. The Government estimates the total level of effort
to be approximately 5.25 person years annually. It is desirable that
the Principal Investigator is an established synthetic organic chemist
and/or medicinal chemist in the synthesis of a variety of steroidal
drugs and optically active, unnatural amino acids with a Ph.D. degree
and will devote a minimum of 25% of her/his time to this project. All
responsible sources may submit a proposal which shall be considered by
the agency. It is anticipated that ONE (1) cost-reimbursement
incrementally funded type contract will be awarded as a result of the
RFP for a period of sixty (60) months, beginning August 1, 1996. The
RFP represents a recompetition of contract N01-HD-1-3137 for the
``Maintenance and Operation of a Synthetic Chemical Facility'' being
performed by the Southwest Foundation for Biomedical Research, San
Antonio, Texas. This announcement is not a request for proposals (RFP).
RFP-NICHD-CD-95-19 will be issued on or about September 14, 1995.
Proposals will be due approximately 60 days thereafter. Copies of the
RFP may beobtained by sending a written request to the address listed
above. Requests may also be made by FAX (301) 402-3676. (236) Loren Data Corp. http://www.ld.com (SYN# 0002 19950825\A-0002.SOL)
A - Research and Development Index Page
|
|