National Institutes of Health, Bethesda, Maryland 20892

A -- THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL PHS 96-1 DUE 120595 POC Research Training and Special Programs Office, (301) 496-1968. National Institutes of Health, Bethesda, MD 20892, Centers for Disease Control and Prevention, Atlanta, GA 30305, and Agency for The above agencies of the Public Health Service are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward meeting the program objectives of the agencies. A SOLICITATION of THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS will be available on or about September 15, 1995, with a closing date of December 5, 1995, for receipt of proposals. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the ''Small Business Research and Development Enhancement Act of 1992'' (Public Law 102-564, dated October 28, 1992). The purposes of the Act are to: (a) expand and improve the SBIR program, (b) emphasize increased private sector commercialization of technology developed through federal R&D, (c) increase small business participation in federal R&D, and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a ''small'' business concern is any business concern that: (a) is independently owned and operated, (b) is not dominant in the field of operation in which it is proposing, (c) has its principal place of business located in the United States, (d) is organized for profit, and (e) has, including its affiliates, no more than 500 employees. Following are the research topicsidentified in the SBIR Contract Solicitation PHS 96-1: NATIONAL INSTITUTES of HEALTH - NATIONAL INSTITUTE ON AGING (NIA): Pharmacologic Manipulation of life span: Administration of 2-deoxyglucose to mimic ''anti-aging'' effects of caloric restriction, Standardized Assessment of Doctor-Older Patient Interactions, NATIONAL INSTITUTE on ALCOHOL ABUSE AND ALCOHOLISM (NIAAA): Computer Software for Use in Classifying Alcohol Use Disorders, Markers of Heavy Alcohol Consumption, NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE ANDKIDNEY DISEASES (NIDDK): Improved Detection Methods for Immunolocalization of Low-Abundance Proteins, Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM), Transplantation of Human Islets or Beta Cells, Development of Partial Estrogen Agonists With Beneficial Effects on Bone, Gene Therapy for Diseases of Interest to NIDDK, Development of Materials for Screening and Recruitment of Clinical Trial Participants, Self-study Materials for Achieving Intensive Management of Glycemic Levels, Temporal and Spatial Control of Gene Activation/Inactivation, Methods to Detect and Quantify Kidney Damage, Selection and Marking Techniques for Hematopoietic Stem Cells, Expansion of the Numbers of Hematopoietic Stem Cells, Development of New Cytokines, NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): Telemedicine Technology for Drug Abuse and HIV Prevention Research in Community Trials, Development of an Improved HIV Risk Assessment/Monitoring Instrument for Use in Clinical Settings, Software Development of Integrated Research Tools, Drug Supply Services Support, Chemical Libraries for Drug Development, Analytical Services Support, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Development of deuterated nitroso spin traps for identifying xenobiotic free radical metabolites, Development of methodologies for utilization of pathology tissue specimens to obtain information on mechanistic bases of toxicologic responses, Chromosome-specific DNA probes for non-human mammals, Automated scoring of sperm with FISH biomarkers, Development and use of protocols for identifying mutations in mouse cells, Development of subchromosome painting kits for the mouse, NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH): Antibodies to HIV-1 gp120: Detection in Formalin-Fixed Human Brain, Kits Combining PCR and Immunocytochemistry: HIV-1 in Human Brain, NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS): Animal Models, Non-Pharmacological Therapy of Epilepsy, Anti-Epileptic Drug Delivery Systems and Formulations, Portable Devices for Sleep Disorder Screening/Monitoring, EEG Home Monitoring for Infants, Near Infrared Spectroscopy (NIRS) for Monitoring of Cerebral Oxygenation, Non-Pharmacological Therapy of Sleep Disorders, Fetal Magnetoencephalography to Assess Fetal Neurological Integrity and Function, Models for Screening Antiepileptic Therapy, Application of Evoked Poentials to the Diagnosis of Sleep Disorders, Development of ''Virtual Reality'' Goggles and Gloves for use in the Administration of Cognitive Tasks, CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) - NATIONAL CENTER for PREVENTION SERVICES (NCPS): Develop Technology to Improve AIDS Reporting to State Health Departments, HIV/AIDS Prevention Curriculum, PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO): Evaluation of Training Impact, AGENCY FOR HEALTH CARE POLICY AND RESEARCH (AHCPR): Consumer Information, Software for Information Capture. The SBIR Contract Solicitation PHS 96-1 will be available on or about September 15, 1995, from: MTL, Inc., 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. In addition, the Solicitation will be available electronically using Business Gold, the National Technology Transfer Center's bulletin board system. Connect via Internet by telneting to ''iron.nttc.edu: or by dialing (304) 243-2560 for high speed modems (9600+) or (304) 243-2561 for 1200-2400 baud modems and logging in as ''guest''. For more information on their electronic bulletin board system, contact: National Technology Transfer Center, Wheeling Jesuit College, 316 Washington Avenue, Wheeling, WV 26003- 6295, phone toll-free in the U.S.: (800) 678-6882. (0249)

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