NIH, OPM, 6120 Executive Blvd, Rockville, MD 20892-7260

A -- THE ANALYSIS AND SUPPORTING DOCUMENTATION FOR ''SHH'' STUDIES SOL 263-96-Q-0046 DUE 110995 POC Christine Albin, Purchasing Agent, (301) 402-3355. This is a notification of intent to procure professional services from Chin Chiang, 5901 Tamar Drive Unit 12, Columbia, MD 21045, which include the following: 1. Shall analyze the function of the SHH (Sonic Hedgehog) gene in mutant mice that include a null mutation of the subject. 2. Shall analyze the function of the ''SHH'' gene during the development of embryonic mice. 3. Shall utilize a thorough knowledge of both the macroscopic and microscopic anatomy of the mouse nervous system, during development, to provide and advance ''SHH'' studies under laboratory conditions. 4. Shall utilize knowledge of both histological and immunological staining procedures for ''SHH'' studies under laboratory conditions. 5. Experimentationa nd analysis shall be performed in existing laboratory space within the Laboratory of Mammalian Genes and Development. National Institute of Child Health and Human Development, NIH. 6. Shall provide a minimum of two thousand (2000) hours of professional work, experimentation, analysis, and associated laboratory efforts to accomplish the subject studies and tasks delineated above. 7. Shall include all necessary descriptive literature/technical information describing the services including but not limited to raw data, written reports, charts/graphs, computer generated results, software to support the conclusions that are developed. Telephone requests will not be honored. Affirmative responses are defined as written responses, with all data enclosed that are required to demonstrate their ability to satisfy this requirement. Written responses must also include complete pricing information, service description containing sufficient technical information to permit agency analysis to establish a bonafide capability to meet the stated requirements as listed above. Responses will be evaluated according to who can meet the requirements at the most favorable terms to the Government, and at the most reasonable price. Only affirmative responses will receive full consideration. Responses are to be received within (15) days from date of issuance. (0299)

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