National Institute of Environmental Health Sciences, Contracts & Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Research Commons Building, P.O. Box 12874, Research Triangle Park, North Carolina 27709

A -- STATISTICAL SUPPORT FOR NIEHS EXPERIMENTAL STUDIES SOL NIH-ES-96-23 DUE 010496 POC Katherine A. Hughes, Contract Specialist (919) 541-0420; Thomas M. Hardee, Contracting Officer, (919) 541-0429 A CPFF level-of-effort-type contract is contemplated for statistical and computationalactivities in support of the National Institute of Environmental Health Sciences (NIEHS),including development and maintenance of various Toxicology Data Management System(TDMS) reports that summarize and analyze data from toxicity and special studies. Thecontractor will also provide statistical evaluation of these studies as needed. It is estimated therewill be 25 toxicity and special studies per year and 12 long-term rodent carcinogenicity studiesduring each of the first two years of the contract and possibly a lesser number (approximately 8)during the final three years of the contract (including the two option years). In addition, therewill be approximately 40 requests annually for ''special'' statistical analyses of tumors ornonneoplastic lesions. Special requirements include the necessity for maintaining personnelproficient in statistics and biostatistics, toxicology/carcinogenesis, toxicokinetics, riskassessment, and statistical computing/data processing. The Contractor must maintain anoperational office in the Research Triangle Park, North Carolina, area. The Governmentanticipates the annual level of effort to be approximately 4 person-years professional, 2 person-years technical, and one person-year clerical. The proposed requirement is a follow-on tocontract N01-ES-15324. All qualified responsible sources may submit a proposal which shall beconsidered. See Note 1. (0304)

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