NIH, OPM, 6120 Executive Blvd, Rockville, MD 20892-7260

A -- MEDRAD SPECTRIS MR INJECTION SYSTEM W/PEDESTAL HEAD MOUNT SOL 263-96-Q(CS)-1582 DUE 120795 POC Mrs. Aretha T. Latimer, Purchasing Agent, Small Purchase Operations Branch, 6120 Executive Blvd., EPS/849C, Rockville, MD 20892. 8734 Professional Service: RFQ 263-96-Q(CS)-1582, POC, Purchasing Agent, Aretha Latimer (301) 496-3340. NIH intends to procure on a SOLE-SOURCE basis under the authority of FAR 6.302-1 for the following service: 1 chg. SMR 200 medrad spectris mr injection system w/pedestal head mount, 1 chg. SSS 200 medrad installed of unit, 1 chg. Sap 200 1 medrad assurance plan, 1 chg. SQK 65 spectris tri pak (50 box). The purpose of this medrad spectris mr injection system w/pedestal head mount is that the Laboratory of Diagnostic Radiology Research (LDRR) has an active research initiative in functional brain imaging using rapid scanning magnetic resonance imaging (fMRI) techniques using rapid bolus injections MR contrast agents in combination with subsecond imaging. These function (fMRI) studies are an essential part of the LDRR research fellowship training program and we are actively pursuing research to map brain functions and monitor changes in cerebral blood volume in response to pharmacological manipulation of the underlying physiology. Due to the confines of the MRI unit, it is extremely difficult to give a reproducible and consistently tight bolus injection of contrast agent which is required to monitor the first pass kinetics of blood flow through any organ but in particular the brain. LDRR has been able to demonstrate that using fMRI techniques it is possible to measure perfusion abnormalities associated with strokes, carotid stenosis and in patients with cerebral tumors. In this regard, a Mechanical Imaging Injector that is compatible with MRI and allows for variable injection rates and delivery of MR contract agent rapidly into the body becomes an essential component of physiological perfusion studies. This MR compatible injector unit needs to be able to function reliably in high magnetic fields up to 1.5 tesla without causing distortions of the MR images due to electronic noise of RF leakage, In addition, the MR injector needs to be able to be triggered by the technician while the individual is operating the MR scanner away from the patient in the control room in order to perform and rigger the bolus injection at an appropriate time during the MR data acquisition. (0307)

Loren Data Corp. http://www.ld.com (SYN# 0005 19951106\A-0005.SOL)