National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, P.O. Box 12874, Research Triangle Park, N.C. 27709

A -- TOXICITY STUDIES IN ANIMALS SOL NIH-ES-96-30 DUE 042696 POC Contact Jacqueline A. Osgood, Contract Specialist, (919) 541-7596 or FAX (919) 541-2712 The purpose of this contract is to conduct short term, in vivo studies that will assist theNational Toxicology Program in the toxicologic characterization of chemicals. The NationalToxicology Program will provide a chemical-specific protocol outline for each chemical to bestudied under this contract. Specific chemicals studies to be conducted will be issued as TaskOrders to the contract. The basic contract award shall provide for the conduct of approximatelyeleven studies per contract year. The Government may, pending the availability of funds,exercise one option in each year of each contract for the conduct of five additional studies. Studydesigns will generally involve daily (gavage or skin paint) or continuous (dosed fee or water)dosing periods. The types of chemicals to be studied may include but shall not be limited toindustrial solvents, plasticizers, food preservatives and colorants, drugs, pesticides, and heavymetals. Most studies will involve rats and mice; however, some studies may include rabbits,guinea pigs, and dogs. These studies will be conducted according to the Specifications for theConduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biologicaland Physical Agents in Laboratory Animals for the National Toxicology Program'' dated August,1992, with subsequent revisions. This work shall be performed in accordance with the GoodLaboratory Practice Regulations established by the FDA for Nonclinical Laboratory Studies;Final Report (Fed. Register, Vol. 52, #172, Friday September 4, 1987, pp 33768-33782; 21 CFRPart 85). Award of one cost-reimbursement, term form, level of effort, task order type contractswith an estimated period of performance of five years is contemplated as a result of thissolicitation. This is a 100% set aside for Small Business. The Government estimates thatapproximately 1.20 senior professional person years, 1.56 professional person years, and 9.61technical person years will be required on an annual basis for each basic contract award. Anadditional 0.60 senior professional person year, 0.76 professional person year, and 4.80 technicalperson years will be required on an annual basis for optional studies. All interested organizationsshould request either a streamlined or full RFP package. If no selection is made, a streamlinedversion of the RFP will be provided, which includes only the Statement of Work, deliverablesand reporting requirements, special requirements and mandatory qualifications (if any), andtechnical evaluation criteria. After examination of these documents, any organization interestedin responding to this RFP must request the entire RFP in writing or by telephone (919) 541-7596or by telefax request (919) 541-2712. All responsible sources may submit a proposal which shallbe considered by the Agency. Expected release date of the RFP is February 27, 1996. SeeNumbered Note 1. (0045)

Loren Data Corp. http://www.ld.com (SYN# 0005 19960215\A-0005.SOL)