Contracts Management Branch, NICHD, National Institutes of Health, Executive Building, Suite 7A07, 6100 Executive Blvd., MSC 7510, Bethesda, MD 20892-7510

A -- SUBCONTRACTING OPPORTUNITIES: PEDIATRIC AND PERINATAL HIV CLINICAL TRIAL CENTERS Sol N01-HD-3-3162, Due 032296, contact, Ms. Carol Nesel, 301/738-8337. The National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH) announces subcontracting opportunities under an ongoing contract with Westat, Inc. Through this contract NICHD sponsors a network of clinical centers which participate in clinical trials of therapies to prevent mother to child transmission of HIV infection and to treat pediatric HIV disease. It is the intent of NICHD and Westat to award additional subcontracts to expand patient access to trails. Preference will be given to clinical centers which can conduct both perinatal and pediatric protocols, which have no other source of NIH funding for HIV-related clinical trials, and which are in areas where patients do not have reasonable access to existing clinical centers. Interested organizations should submit five copies of a statement of capabilities which must include the following: 1) a description of staff qualifications (include CVs of the proposed pediatric Principal Investigator (PI), obstetric PI if an obstetric component is included); 2) description of HIV-related and non-HIV-related research experience (types and number of studies including drug trails, natural history studies, etc., total patient enrollment per study); 3) a description of existing clinics for HIV-infected women (pregnant and non-pregnant) and children, number of HIV-infected pregnant women and HIV-exposed and infected children seen in the clinics annually (include a description of disease stage and anti-retroviral treatment experience of children seen in clinic); 4) a description of the physical facilities where trails would be conducted (including access to inpatient facilities, such as GCRC, for phase 1 trails); and 5) description of existing access to clinical trails for HIV-infected women and any alternative access to clinical trials for HIV-infected children in your geographic area. Capability statements addressing all of the above should be submitted to Ms. Carol Nesel, Associate Director, Westat, Inc., 1650 Research Boulevard, Rockville, MD 20850. The deadline for submission is 2:00 p.m. est March 29, 1996. (052)

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