National Cancer Institute, Research Contracts Branch, TCS 6120 Executive Blvd, EPS/Room 603, MSC 7220, Bethesda MD 20892-7220

H -- COMPUTER BASED SEARCHES FOR CHEMICAL STRUCTURES SOL NCI-CM-67247-08 DUE 040196 POC Mr. Todd C. Cole, Contract Specialist, (301) 496-8620. One cost-reimbursement contract is expected to be awarded to assist the Developmental Therapeutics Program (DTP), Division of Cancer Treatment Diagnosis and Centers (DCTDC) of the National Cancer Institute (NCI). The DTP database includes chemical and biological information on approximately 500,000 compounds. There is a continuing need to perform high volume computerized full and substructure chemical searches of the DTP database in support of various segments of the Program, including: compound acquisition, compound screening and evaluation committees, National Cooperative Drug Discovery Groups, and grantee requests. Other searches involve published literature databases, such as STN and DIALOG, to provide the Drug Synthesis and Chemistry Branch (DS&CB) and Pharmaceutical Resources Branch (PRB) with rapid access to citations relevant to the resynthesis effort. Systematic nomenclature also is generated for selected compounds. The Contractor shall support the Developmental Therapeutics Program through the described substructure and full structure chemical searches as well as data item searches. Bibliographic searches shall be performed utilizing databases such as NLM/MEDLARS, STN, DIALOG, and other systems. The Contractor shall analyze each request, develop an appropriate search strategy, phrase the search question, process the query interactively, check and review the output, and generate the output report. The Contractor shall generate systematic nomenclature for selected compounds. The Principal Investigator shall have a Masters Degree in organic chemistry or equivalent experience. In addition, the Principal Investigator shall have training in chemical documentation and retrieval and substructure searching. The availability of an additional chemist with chemical nomenclature knowledge and experience for four to eight hours a week is also preferable. The Contractor shall perform the work ''on-site'' at the DTP offices located on 6130 Executive Boulevard in Rockville, Maryland. Adequate space and equipment for performance of the work will be provided. The proposed contract is 100 percent set-aside for small business concerns with a SIC code of $7 million ($7M). NO collect calls will be accepted See Numbered Note(s): 1. (0072)

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