NIH, NIAID, CMB, Solar Blvd., Room 3C07, 6003 Executive Blvd., MSC- 7610, Bethesda, MD

A -- PRECLINCIAL EVALUATION OF THERAPIES FOR CRYPTOSPORIDIUM PARVUM INFECTION SOL RFP-NIH-NIAID-97-05 DUE 081596 POC Bruce E. Anderson, Contracting Officer (301) 496-8371. The NIH, NIAID, DAIDS, has a requirement to quantitatively evaluate therapeutic agents for efficacy against Cryptosporidium parvum infection in a standarized, validated immunocompromised mouse model test system. In vivo studies will include evaluation of therapies in combination in the primary mouse model; evaluation of therapies in a validated, standardized animal model for hepatobiliary disease; and evaluation of therapies using alternative strains of Cryptosporidium. Therapeutic agents will be evaluated for efficacy in a standardized, reproducible, and validated in vitro test system using intact organisms. The offeror should have available a primary mouse model of Cryptosporidium infection and an in vitro system (including relevant Cryptosporidium isolates) suitable for the evaluation of therapies with potential for treatment of Cryptosporidium infections in people with AIDS. It is anticipated that one (1) cost-reimbursement, level-of-effort type contract will be awarded for a period of five (5) years beginning on or about July 23, 1997. It is anticipated that 1,675% total effort will be needed for this acquisition during the five-year period. RFP NIH-NIAID-DAIDS-97-05 will be available electronically on or about April 15, 1996, and may be accessed through either the NIH Gopher or the NIH Home Page by using the following electronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOVPORT 70. (You should now be in the NIH Gopher.) Select ''Grant and Research Information,'' then select ''R&D Request for Proposals (RFP).'' 2) NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov. Once you are at the NIH Home Page, select ''Grants and Contracts,'' then select ''R&D Requests for Proposals (RFP).'' Responses to this RFP will be due on August 15, 1996. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. Inquiries may also be faxed to Mr. Bruce Anderson at (301) 402-0972 or sent by electronic mail to ba9i@nih.gov. No collect calls will be accepted. (0085)

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