NIH, NIAID, CMB, Solar Bldg., Room 3C07, 6003 Executive Blvd., MSC- 7610, Bethesda, MD

A -- PRECLINICAL EVALUATION OF THERAPIES FOR PNEUMOCYSTIS CARINII INFECTION SOL RFP-NIH-NIAID-97-04 DUE 081596 POC Nancy M. Hershey, Contracting Officer (301) 496-0193. The Opportunistic Infections Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement to develop therapies for the treatment of AIDS and associated opportunistic infections. The purpose of this RFP is to quantitatively evaluate therapeutic agents for efficacy against Pneumocystis carinii in a standardized, validated mouse model test sytem. In vivo studies will include evaluation of therapies in combination in the primary mouse model, drug evaluation in prophylaxis protocols in the primary mouse model, and evaluation of treatment therapies in a rat model. Therapeutic agents will be evaluated for efficacy in a standardized, reproducible and validated in vitro test system which employs intact organisms. The offeror should have available a mouse testing system and an in vitro system (including relevant Pneumocystis strains) suitable for the evaluation of therapies with potential for treatment of Pneumocystis carinii infections in people with AIDS. It is anticipated that one (1) cost reimbursement, level-of-effort type of contract will be awarded for a period of five (5) years beginning on or about July 10, 1997. It is estimated that 1,400% total effort will be needed for this acquisition during the five-year period. RFP NIH-NIAID-DAIDS-97-04 will be avaliable electronically on or about April 15, 1996, and may be accessed through either the NIH Gopher or the NIH Home Page by using the following electronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOVPORT 70. (You should now be in the NIH Gopher.) Select ''Grant and Research Information,'' then select ''R&D Request for Proposals'' (RFP). 2) NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov. Once you are at the NIH Home Page, select ''Grants and Contracts,'' then select ''R&D Requests for Proposals (RFP).'' Responses to this RFP will be due on August 15, 1996. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. Inquiries may also be faxed to Ms. Hershey at (301) 402-0972 or sent by electronic mail to nh11x@nih.gov. No collect calls will be accepted. (0085)

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