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A -- PRECLINICAL EVALUATION OF THERAPIES FOR MYCOBACYTERIUM AVIUM INFECTION SOL RFP-NIH-NIAID-97-01 DUE 081596 POC Joyce U. Sagami, Contract Specialist 301-496-7118. The Opportunistic Infections Research Branch, Therapeutics Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement to develop therapies for the treatment of AIDS and associated opportunistic infections. The purpose of this RFP is to seek responsible offers to quantitatively evaluate therapeutic agents for efficacy against Mycobacterium avium in a standardized, validated mouse model test system. In vivo studies will include evaluation of therapies in combination and drug evaluations in prophylaxis protocols. Therapeutic agents will be evaluated for efficacy in standardized, reproducible, and validated in vitro culture and intracellular test systems. The offeror should have available a mouse testing system and in vitro systems (including relevant mycobacterial strains) suitable for evaluation of therapies with potential for treatment of Mycobacterium avium infections in people with AIDS. It is anticipated that one (1) cost reimbursement, level-of-effort type contract will be awarded for a period of five (5) years beginning on or about July 23, 1997. It is estimated that 1,450% total effort will be needed for this acquisition during the five-year period. RFP NIH-NIAID-DAIDS-97-01 will be available electronically on or about April 15, 1996, and may be accessed through either the NIH Gopher or the NIH Home Page by using the following electronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOVPORT 70. (You should now be in the NIH Gopher.) Select ''Grant and Research Information,'' then select ''R&D Request for Proposals'' (RFP). 2) NIH Home Page (via the World Wide Web): Access the NIH Home Page by using http://www.nih.gov. Once you are at the NIH Home Page, select ''Grants and Contracts,'' then select ''R&D Requests for Proposals (RFP).'' Responses to this RFP will be due on August 15, 1996. Any responsible offeror may submit a proposal which will be consided by the Government. This advertisement does not commit the Government to award a contract. Inquiries may also be faxed to Ms. Sagami at (301) 402-0972 or sent by electronic mail to js73b@nih.gov. No collect calls will be accepted. (0085)

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