National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, 4401 Building, P.O. Box 12874, Research Triangle Park, NC 27709

A -- LONG-TERM EFFECTS OF PRENATAL DIETHYLSTILBESTROL (DES) EXPOSURE ON BONE POC Contact James Doyle, Contracting Officer, (919) 541-0424 The National Institute of Environmental Sciences intends to negotiate with the Universityof Chicago for a two-year contract involving the Chicago DES cohort data base in order toexamine the long-term effects of prenatal exposure to DES on bone density and bonemetabolism in the daughters of the cohort. Authority: 41 U.S.C. 253(c)(1) as set forth in FAR6.302-1. This source is the only known responsible source in the United States to havedeveloped a DES cohort derived from a randomized clinical trial of DES with an establishedcontrol and comparison group. The cost to the Government which would be involved in firstdeveloping a control and comparison group and then updating and expanding the data base forthe purposes stated above, make competition unfeasible. See Note 22. (0087)

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