Contracts Management Branch, National Institute of Neurological Disorders and Stroke, NIH, Federal Building, Room 901, Wisconsin Ave., MSC 9190, Bethesda, MD 20892-9190

A -- PRODUCTION AND BIOSAFETY TESTING OF A RETROVIRAL VECTOR SUPERNATANT FOR GENE THERAPY OF FABRY DISEASE Sol RFP No. NIH-NINDS-96-06, Due 053196, contact point, Raina Cervantes, 301/496-1813, Contracting Officer, Kirkland L. Davis, 301/496-9203. The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), will solicit proposals for the production of 30 liters (10 liters each year) of high-titer retroviral supernatant solutions under GMP conditions, biosafety testing, and delivery for the transduction of stem and progenitor cells for patients with Fabry disease. Offerors are required to have a facility that has been inspected by the FDS and is in compliance with established current Good Manufacturing Practices (GMP) and current Good Laboratory Practices (GLP). Offerors must have personnel on staff with established experience in the production of retroviruses under GMP conditions. It is anticipated that one (1) contract will be awarded for a maximum period of three (3) years. Payment will be on a cost-reimbursement type basis. This is not a Request for Proposals. Requests for Proposals (RFP) No. NIH-NINDS-96-06 will be issued on or about April 15, 1996 with responses due approximately forty-five days thereafter. To receive a copy of the RFP, submit a written request or FAX request to 301/402-4225. Requests must cite the RFP number references above. Please supply this office with two (2) self-addressed mailing labels. All responsible sources may submit a proposals which shall be considered by the Government. Refer to numbered note 26. (088)

Loren Data Corp. http://www.ld.com (SYN# 0003 19960403\A-0003.SOL)