National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, P.O. Box 12874, 4401 Building, Research Commons, Research Triangle Park, NC 27709

A -- DETERMINATION OF GENETIC SUSCEPTIBILITY TO LUNG CANCER IN FAMILIES FROM SOUTHERN LOUISIANA SOL NIH-ES-96-33 POC Contact Velvet M. Torain, Contract Specialist, 919/541-0440; Phillip D. Jones, Contracting Officer, 919/541-0426 The National Institute of Environmental Health Sciences intends to negotiate a contractwith Louisiana State University, Medical Center, 433 Bolivar Street, New Orleans, LA70112-2223 to conduct a study to determine the genetic susceptibility to lung cancer in familiesfrom southern Louisiana for the National Center for Human Genome Research's Division ofIntramural Research/Center for Inherited Disease Research (NCHGR). Specifically, LouisianaState University will be required to apply the tools necessary to ascertain lung cancer patientsin a rapid ascertainment network, and to collect data and biologic specimens from selectedlung cancer patients and their families to be delivered to the Government so that geneticlinkage analyses can be performed. Specifically the tasks to be performed are: (1) use anexisting rapid-surveillance system to collect data on patients diagnosed with lung cancerbetween September 30, 1996 through September 29, 1999 in all hospitals diagnosing lungcancer patients within 24 parishes (counties) in Southeastern Louisiana; (2) in families wherethere are at least two relatives affected with lung cancer in addition to the probands, thecontractor shall contact all 1st and 2nd degree relatives of the probands and appropriatespouses (next of kin if spouse is deceased) to obtain cancer history, environmental and lifestylerisk-factor information, blood samples or tissue samples (the latter from deceased affectedindividuals); (3) follow-up on a set of 9 families previously ascertained during preliminarystudies, each having at least 3 persons affected with lung cancer, for inclusion in the linkagestudy. The Contractor shall extend these families by including additional relatives in thestudy. Blood samples shall be collected on all living informative members of these familieswho have not previously been sampled, and tissue samples will be obtained, if possible, for alldeceased family members; and (4) the Contractor shall provide blood samples, a plan forsubmission of clinical information, clinical information, and questionnaires as specified by theProject Officer. It is estimated that approximately 400 new patients will be reported to theContractor per year, and it is anticipated that the Contractor will enroll (contact and sendquestionnaires) to about 200 patients per year. Approximately 15-20 families may be recruitedduring the first three years of the contract to participate in the linkage analysis. Authority: 41USC 253(c)(1), as set forth in FAR 6.302-1--Only One Responsible Source. Louisiana StateUniversity, Medical Center (LSUMC) is the founder of the Rapid Case AscertainmentNetwork, which took approximately one year to establish. The existing rapid case-ascertainment network in southern Louisiana has been successful in collecting 9 pedigreesinformative for lung cancer linkage analysis and therefore is likely to be able to collect moresuch families over the period of this study. It would be too costly, monetarily and time wise,for the 33 hospitals who are seeing lung cancer patients in the target area and who alreadyhave a research agreement with LSUMC to sever this agreement and enter into a new researchagreement with another source when the current arrangement is working so well. In addition,it would take another source a year or more to obtain the necessary approvals from each of thehospitals and to develop and implement the necessary protocols. It would then take anadditional six months or more to establish a cohort the size of the existing one. This wouldcause unacceptable delays and the research project would be engendered while another sourcesets up a rapid ascertainment system. It is to the Government's benefit to take advantage ofthis existing data base and cohort. It is estimated that it would take approximately 16,900direct labor hours to complete the work. Any other interested sources desiring considerationfor this requirement must fully identify their interests and capabilities to the Contract Specialistlisted above. See Numbered Notes 22 and 26. (0124)

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