National Cancer Institute, Research Contracts Branch, PCCS, 6120 Executive Blvd, EPS/Room 635, Bethesda, MD 20892-7226

A -- PROSTATE, LUNG, COLORECTCAL, AND OVARIAN (PLCO) CANCER SCREENING TRIAL - LABORATORY SOL N01-CN-25404 POC Susan K. Hoffman, Contracting Officer, 301-496-8603. The National Cancer Institute, Division of Cancer Prevention and Control, Early Detection Branch intends to negotiate with the Regents of the University of California, Los Angeles for the inclusion of new work under the current contract as the Laboratory for the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. This contractor conducts Prostate Specific Antigen (PSA) and CA125 assays for the Trial. An array of biomolecular assays are developing very rapidly (i.e. replacement of CA125 with CA125-II). NCI needs to be able to characterize a new or modified method in order to be able to interpret the results of the PLCO Trial; therefore, the statement of work has been modified to include performance of special studies which would determine the behavior of new assays, which may improve or replace existing assays in the trial is required. Samples on which these studies would be performed physically reside at UCLA. Authority: 41 USC 253(c)(1), as set forth in FAR 6.302-1. No collect calls will be accepted See Numbered Note(s): 22. (0131)

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