National Institute of Child Health and Human Development, Contracts Management Branch, Executive Building, Suite 7A07, 6100 Executive Blvd. MSC 7510, Bethesda, Maryland 20892-7510

A -- EFFICACY TRIAL OF SPERMICIDAL AGENTS SOL RFP-NICHD-CRE-96-09 DUE 091396. Contact Charles W Grewe, Contracting Officer (301) 496-4611. The Contraceptive and Reproductive Evaluation Branch of the Center for Population Research, National Institute of Child Health and Human Development, requires information on the contraceptive efficacy of different spermicide formulations marketed in the U.S. Secondary objectives include measurement of safety (adverse reactions) and acceptability. A clinical trial is requested which will rely on an educational/motivational component to maximize the number of consistent and correct users of spermicides during the trail period. We are seeking organization(s) capable of designing and conducting an observational study among women of reproductive age, obtaining reproductive histories, training subject in coital log use, and perform clinical testing to ascertain chemical pregnancies. Offerors should have knowledge of reproduction and contraception, expertise in the conduct of large clinical trials, and experience in analysis of large research data sets. Emphasis will be placed in the ability of the Offeror to recruit and follow adequate numbers of subjects during the course of the study. The Government estimates the total required effort to be approximately 17.1 staff years to complete a six-month follow-up of at least 300 women in each of four observational arms over a performance period of four years. It is estimated that from one to four cost-reimbursement, incrementally funded contract will be awarded. This announcement is not a request for Proposals (RFP). RFP-NICHD-CRE-96-09 will be issued n or about June 10, 1996. Proposals will be due 90 days thereafter. Copies of the RFP may be obtained by sending a written request to the address listed above. Please enclose a self-addressed label. FAX requests will be accepted at (301) 402-3676. (141)

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