National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, P. O. Box 12874, Research Triangle Park, NC 27709

A -- STUDIES OF CHEMICAL DISPOSITION IN MAMMALS SOL NIH-ES-96-35 DUE 082196 POC Marilyn B. Whaley, 919/541-0416, Contract Specialist The purpose of this project is to conduct chemical disposition studies in mammals to support the bioassay program of the National Toxicology Program (NTP). The general objective of this project is to procure detailed chemical disposition data from a number of studies (approximately 3-5 annually) of selected environmental contaminants or model compounds in laboratory rats (Fischer 344) and or mice (B6C3F1). Most studies will address the disposition of organic chemicals or environmental contaminants; however, studies of inorganic compounds may also be requested. One or more additional studies per year may investigate the comparative metabolism of chemicals in human and rat liver slices in vitro. Individual studies may vary in complexity from preliminary investigations of chemical absorption to detailed studies of all phases of chemical disposition, toxicokinetics, and metabolism. The immediate goal of these studies is to determine more accurately the doses for NTP bioassay studies. The long-range goal is the accumulation of data that will permit a better assessment of structure-activity relationships chemical absorption, metabolism and disposition in laboratory animals and to better compare metabolic pathways in laboratory animals and humans. Award of up to two (2) cost reimbursement, term-form, level-of-effort type contracts with a period of performance of five years are contemplated as a result of this solicitation. The Government estimates approximately 1.75 professional and 2.75 technical for a total of 4.5 person years per year for each contract award. Interested organizations should request either a streamlined or full RFP package. Requests for the solicitation must reference RFP No. NIH-ES-96-35 and bedirected to the office listed above. If no selection is made, a streamlined version of the RFP, which includes only the Statement of Work, deliverables and reporting requirements, special requirements, and technical evaluation criteria, will be provided. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP in writing or by telefax request (919) 541-2712. The electronic version of the CBD synopsis and the RFP(which will be available on or about June 21, 1996) are available by typing: http://contracts.niehs.nih.gov or Gopher://contracts.niehs.nih.gov. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is June 21, 1996 with proposals due on August 21, 1996.(0151)

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