National Cancer Institute, Research Contracts Branch, TCS, 6120 Executive Blvd, EPS/RM 603 Bethesda, MD 20892-7220

A -- DEVELOPMENT OF DOSAGE FORMS AND DELIVERY SYSTEMS FOR ANTITUMOR AND ANTI-AIDS AGENTS SOL NCI-CM-77017-28 DUE 082696 POC Carolyn E Barker, Contract Specialist, at (301) 496-8620 or Therese M Dick, Contracting Officer, at (301) 496-8620. The Pharmaceutical Resources Branch of the Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute (NCI) is seeking contractors to develop acceptable dosage forms for compounds to be subsequently evaluated in cancer and HIV patients and to carry out innovative studies leading to more effective approaches for the intravenous delivery of compounds that possess limited solubility and/or stability. NCI will select and provide the compounds to be studied. In addition to solubility problems, the projects will require considerable analytical work, particularly the development of a stability-indicating assay to monitor the integrity of the parent compound during the formulation studies. These investigations will be directed toward a pharmaceutical dosage form that will meet certain solubility and stability targets determined by the Government. The Principal Investigator on this project should possess a Ph.D. in Pharmaceutics or Medicinal Chemistry and should also have at least three years experience in the development of injectable formulations. It is anticipated that three (3) cost-reimbursement term type contracts will be awarded for a base-period of three (3) years, with two one year options for each contract. The proposed contract project represents a recompetition of Contracts N01-CM-27755 (University of Kansas), N01-CM-27756 (University of North Carolina), N01-CM-27757 (University of Arizona), N01-CM-27720 (University of Utah). RFP NCI-CM-77017-28 will be available to all interested offerors on or about June 24, 1996, with a response date of August 26, 1996, for the receipt of proposals. A copy of RFP No. NCI-CM-77017-28 may be obtained by requesting by FAX (301) 402-6699, OR in writing to Ms Carolyn Barker, Contract Specialist, Treatment Contracts Section, Research Contracts Branch, National Cancer Institute, Executive Plaza South, Room 603, 6120 EXECUTIVE BLVD MSC 7220, BETHESDA MD 20852-7220, OR by E-Mail address: barkerc@rcb.nci.nih.gov . No collect calls will be accepted. (0157)

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