Centers for Disease Control and Prevention (CDC), Procurement & Grants Office, 255 East Paces Ferry Road, N.E., Room No. 419 Atlanta, Georgia 30305

70 -- MOLECULAR MODELING SOFTWARE SOL 96-150(N) POC Contact Mary Sittler, Contract Specialist at (404)842-6553 This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulations (FAR), Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are requested and a written solicitation will not be issued. This is Solicitation 95-165-N and is issued as a Request for Proposals (RFP). The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular Number 90-37. The procurement is unrestricted. The standard industrial classification code (SIC) is 7372. Small business size standard: Average annual receipts for each of the 3 preceding fiscal years do not exceed $18,000,000. CONTRACT LINE ITEMS: The CDC intends to purchase one copy of the following software: Discover molecular mechanics software, Insight II molecular modeling software, Profiles-3D protein structure analysis software module, Homology software module, Apex-3D QSAR software module, Search and Compare small molecule conformation software module, Biopolymer protein binding software module, and conversion of existing node locked licenses to floating licenses. DESCRIPTION OF REQUIREMENTS TO BE ACQUIRED: Software to perform molecular modeling, simulations and calculations on organic and biological molecules and on mineral surfaces. Software shall run on an existing Silicon Graphics High Impact workstation. Software shall provide the ability to: (1) search databases of converted protein structures to find structural homologues where there is a lack of sequential homology; (2) integrate a variety of constraints derived from an experiment or prior knowledge for integration into the calculations of proteins homology searches; (3) investigate and manipulate surface chemistry of structures and crystals based on quantum mechanics as well as molecular mechanics and exchange the data calculations seemlessly; (4) investigate surface and protein interaction concurrently; (5) perform fully integrated pharmacophore hypothesis generation based on activity data and 3D QSAR tools; (6) perform quantum mechanical calculations both in solution and solid state; (7) compare results from analytical tools with spectra generated from computation. Software shall be fully integrated and compatible with existing Biosym Insight II, Discover and Solids software including: (1) fully compatible file formats; (2) an integrated environment which allows all software modules to be run under a single interface; (3) the ability to use any or all software modules on a single modeling problem; (4) the ability to use new software modules under the existing Insight II interface. The FAR provisions at 52.212-1, Instructions to Offerors--Commercial Items and FAR 52.212-2, Evaluation--Commercial Items apply to this acquisition. EVALUATION FACTOR: The Offeror must be able to demonstrate the technical capability of their software to perform all of the features identified above. Technical proposals and cost or price will be of approximately equal importance. It is the intent of the Government to make a single award to the responsible offeror whose proposal conforms to all requirements of the solicitation and is considered to be most advantageous to the Government. The offeror is advised that FAR provisions 52.212-4, Contract Terms and Conditions--Commercial Items and 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items apply to this acquisition. Offers are due July 5, 1996, 2:00 p.m. local time. Submit the following to the Centers for Disease Control and Prevention/Offerors are to include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications--Commercial Items, with the offer. PGO, Attn: Mary Sittler, 255 East Paces Ferry Road, NE, Atlanta, GA 30305; (1) an original and three copies of a completed SF 1449, signed by an official authorized to bind the organization; (2) Price List for the software package/packages that can meet the criteria above; (3) A completed copy of the provision at 52.212-3, Offeror Representations and Certifications--Commercial Items, with the offer; (4) data required under Evaluation Factor; and (5) acknowledgment of solicitation amendments, if any. Offers that fail to furnish the required information, or reject the terms and conditions of the solicitation may be excluded from consideration. Award of a firm-fixed price contract will be made on or about July 9, 1996. The software will be delivered to DHHS,PHS,CDC,NIOSH ALOSH, 1095 Willowdale Rd, Morgantown WV 26505-2845 fob destination. Information regarding this solicitation can be obtained from Mary D. Sittler at (404) 842- 6769. All other information published in the original synopsis is correct.(0170)

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