DHHS/PHS/FDA/Office of Facilities, Acquisition and Central Services, Contracts Operations Branch, HFA-512, 5600 Fishers Lane, Park Building, Room 3-32, Rockville, MD 20857

A -- DEVELOP THEORETICAL MODEL TO RELATE ULTRASONIC MEASUREMENTS SOL FDA 363914-96 DUE 071596 POC Trudy Dartouzos, Contract Specialist, 301/443-4420 Engineering analysis needed to develop theoretical model to relate ultrasonic measurements to properties of tissue to incorporate general scattering model, including backscatter from regularly spaced scatterers and diffuse scatterers. Investigate into determinants of the empirical observation of changes in measured mean scattered spacing in liver with hepatitis, relate measurements of acoustic properties of tissue. A detailed analysis of algorithm (FDA will provide algorithm in the form of FORTRAN program and data base of paired data sets - ATL and Diasonics). Develop and compare signal processing algorithms to extract the features from digitized radio-frequency data, devise method for decomposing signal into incoherent components and validate model on existing data sets (tissue-mimicking phantom, liver and kidney). Write computer program to perform split-spectrum analysis and divide data into low-band pass filtered and high-band pass filtered channels to be tested on phantom, liver, kidney, and prostate data to be written in C or C++. Apply theory and methods to prostate data, perform analysis to estimate the relative strengths of coherent and incoherent components of ultrasonic backscatter from prostate, compare normal and diseased data sets, develop and write software to measure texture features from ultrasonic images in C or C++. Combine features measured, utilize methods of classification including linear and quadratic discriminants and neural nets. Develop software to be integrated into larger tissue characterization package being developed using C or C++ to run on Windows 95 system. (0176)

Loren Data Corp. http://www.ld.com (SYN# 0003 19960625\A-0003.SOL)