National Cancer Institute, Research Contracts Branch, TCS, 6120 Executive Blvd, EPS/RM 603 Bethesda, MD 20892-7220

A -- SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS AND CHEMOPREVENTIVE AGENTS SOL NCI-CB-77022-75 POC Bernice Evans Belt, Contract Specialist, 301-496-8620 Dorothy M. Coleman, Contracting Officer, 301-496-8620. The Chemical and Physical Carcinogenesis Branch of NCI's Division of Cancer Biology, has a continuing requirement for the synthesis, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. The compounds are to be prepared in exploratory syntheses on a small scale and then prepared in a production run to yield one to several grams of sufficiently pure material (generally 99+ percent). Compounds are to be characterized by a meaningful combination of appropriate techniques including specific activity; melting points; ultraviolet, visible and infared spectroscopy; and NMR or mass spectroscopy. Major responsiblilties are: 1) resynthesis of polycyclic aromatic hydrocarbon PAH derivatives by established procedures for the restocking of NCI's Chemical Carcinogen Reference Standards Repository as necessary, and 2) development of synthesis of selected chemical carcinogens, chemopreventive agents and certain of their metabilites or derivatives. Distribution to the research community will be handled by the repository contractor for all unlabeled compounds. Labeled compounds will be subdivided and shipped to designated recipients in the research community by the synthesis contractors or the radiorepository contractor. The contractors shall be required to provide analytical, handling, and storage data with all shipments. A high degree of cooperation with NCI, the repository contractor, and other synthesis program contractors is necessary. This is a recompetition of two existing contracts for similiar work. RFP-NCI-CB-77022-75 will be issued on or about July 30, 1996. The Government anticipates 1 or 2 contracts wil be awarded on an incrementally funded basis for a period of five years. The Standard Industrial Classification Code (SIC) is 8731. No Collect Calls accepted. (0178)

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