National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, Building 4401, Research Commons, P. O. Box 12874, Research Triangle Park, NC 27709

A -- REPRODUCTIVE TOXICOLOGY TEST SYSTEMS SOL NIH-ES-96-36 DUE 100796 POC Velvet M. Torain, Contract Specialist, (919)541-0400, Phillip D. Jones, Contracting Officer, (919) 541-0426, FAX Number (919) 541-2712 The objective of this project is to test environmental chemicals in laboratory animals (mice, or rats, or rabbits), and develop data on the general and reproductive toxicology of such chemicals. This work involves evaluating tissues and vaginal cytology slides sent from other toxicology labs (spermatid count and vaginal cytology evaluations) and performing in vivo toxicology studies in-house. The contractor shall be responsible for maintaining animals in environmentally-controlled facilities, and providing technical assistance to the National Toxicology Program-designated toxicology laboratories. This work shall be performed in a manner compatible with the NIEHS Laboratory Health and Safety Minimum Requirements for Contractors. This work shall also be conducted in accordance with the Chemistry Requirements for Toxicology Testing Laboratories Which Require Central Analytical Chemistry Support, Revision 3.2, dated October 18, 1995. All lab records shall be kept in accordance with FDA Good Laboratory Practice Regulations for Non-Clinical Laboratory Studies; Final Report (Fed. register, Friday, September 2, 1987, pp33768-33782 (21 CFR part 581)). The Contractor shall have demonstrated experience in performing reproductive toxicology studies and have an operational facility with appropriate staff and procedures for performing reproductive toxicology studies. The estimated period of performance is five (5) years. The Government estimates this five year period may require approximately 58,250 hours of professional time, and 78,250 hours of technical time. This acquisition is a total small business set-aside, the size standard for which is 500 employees. See Numbered Note 1 and Note 26. (0207)

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