National Cancer Institute, Research Contracts Branch, TCS 6120 Executive Blvd, EPS/RM 603 Bethesda, MD 20892-7220

A -- OPERATION OF A REGISTRY OF TUMORS IN LOWER ANIMALS SOL NCI-CB-77021-34 POC Yolanda Young, Contract Specialist, 301-496-8620 Dorothy Coleman, Contracting Officer, 301-496-8620. The Office of the Director, Division of Cancer Biology, within the National Cancer Institute, has a continuing requirement for the ''Operation of a Registry of Tumors in Lower Animals.'' The current contract is with the Smithsonian Institution, Washington, D.C. with a subcontract to the George Washington University Medical Center. During the past 30 years, the Registry of Tumors in Lower Animals (RTLA) has developed into a unique resource which facilitates the study of neoplasms and related disorders in cold-blooded vertebrate and invertebrate animals by serving as a centralized repository of pathological materials and related data, i.e., a specimen repository, a diagnostic center, and an information center. The RTLA maintains the premier database in the world on neoplasms in lower animals. Tumor specimens from field studies in lower animals may be submitted to the RTLA for pathological indentification and evaluation, thereby, serving to enhance the acquisition of unique specimens and expand overall knowledge in this area. The RTLA also serves as a clearinghouse for information on tumors in lower animals, answering requests for information from scientists and others all over the world. The RTLA is becoming increasingly important because of its relevance to many areas of toxicology research, for example, the development of alternative methods to the animal bioassay (in particular, the use of the fish bioassay for testing chemicals that are suspect carcinogens), and the validation of interspecies extrapolation. This is a recompetition of an existing contract for similar work. RFP-NCI-CB-77021-34 will be issued on or about 9/9/96. The government anticipates 1 contract will be awarded on an incrementally funded basis for a five year period. The Standard Industrial Classification Code (SIC) is 8731. No collect calls accepted. (0236)

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