National Institutes of Health, Bethesda, MD 20892 & Centers for Disease Control and Prevention, Atlanta, GA 30305

A -- THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL PHS-97-1 DUE 110506 POC Office of Extramural Programs, Office of Extramural Research, (301) 496-2770 THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL (PHS 97-1) DUE 110596 POC Office of Extramural Programs, Office of Extramural Research, (301) 435-2770. National Institutes of Health, Bethesda, MD 20892 and Centers for Disease Control and Prevention, Atlanta, GA 30305 of the Public Health Service are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward meeting the program objectives of the agencies. A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS {PHS 97-1), with a closing date of November 5, 1996, for receipt of proposals, will be available electronically on or about September 6, 1996, through the National Institutes of Health Home Page on the World Wide Web at: HTTP://WWW.NIH.GOV. A limited number of hard copies of the Solicitation will be available on or about September 13, 1996, from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Included in the Solicitation is a ''Fast-Track'' pilot initiative. Fast-Track is a parallel review option available to those small business concerns (offeror organizations) whose proposals satisfy additional criteria which enhance the probability of the project's commercial success. Fast-Track offers two major advantages: (1) concurrent peer review of both Phase I and Phase II projects and (2) minimal or no funding gap between Phase I and Phase II. A ''Commitment Appendix'' and a ''Product Development Plan Appendix'' must accompany the Phase II proposal. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the ''Small Business Research and Development Enhancement Act of 1992'' (Public Law 102-564, dated October 28, 1992). The purposes of the Act are to: (a) expand and improve the SBIR program; (b) emphasize increased private sector commercialization of technology developed through federal R&D; (c) increase small business participation in federal R&D; and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a ''small business concern'' is any business concern that: (a) is independently owned and operated; (b) is not dominant in the field of operation in which it is proposing; (c) has its principal place of business located in the United States; (d) is organized for profit; and (e) has, including its affiliates, no more than 500 employees. Following are the research topics identified in the SBIR Contract Solicitation (PHS 97-1): NATIONAL INSTITUTES OF HEALTH (NIH) - NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA): Antibodies to peptides and proteins mediating alcohol-related behaviors (from DBR); NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES (NIAMS): Markers of Osteoarthritis; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK): Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM); Transplantation of Human Islets or Beta Cells; Improved Methods for Production of Clinical Gene Therapy Vectors for Diseases of Interest to NIDDK; Development of Materials for Screening and Recruitment of Clinical Trial Participants; Self-study Materials for Achieving Intensive Management of Glycemic Levels; Methods to Detect and Quantify Kidney Damage; Acute Renal Failure; New Noninvasive Body Iron Test; NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): Drug Supply Services Support; Develop Animal Model(s) with Compromised Immune Function Induced by Abused Drug(s) to Screen Potential HIV/AIDS Medicating Agents; Develop Animal Models to Assess the Potential for Genetic Predisposition or Increased Sensitivity to Cardiovascular Complications Associated with Abused Substance(s); Computerized Neuropsychological Testing Software; Development of a Computerized Problem Oriented Screening Instrument for Teenagers (Posit); Development of Improved HIV Risk Reduction Questionnaire and Interview; Questionnaires or Brief Interviews for Assessment of Drug Abuse in Individuals Seen in Primary Health Care Settings; Handbook for Conducting Drug Abuse Research with Ethnic/Racial Minority Populations; International Drug Abuse Epidemiology Data Bank; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Development of a Transgenic Teleost Animal Model for Assessing Mutagenesis; Better Nitrone Spin Traps for Oxygen-Centered Radicals; Commercialization of Laboratory Methods for Assessing the Genetic Responses to Chemicals; Device/Capability for Quantitative Assessment of Bone Strength in Rodents; Methods for Assessing the Estrogenicity and Other Endocrine Activity of Environmental Chemicals; Development of Device and Procedure for Collecting DNA by Mail with a Cheek Swab; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI): Stage- and Tissue-Specific Animal Models of Hemophilia; Radio-frequency Coils for High Field MRI; ECG Monitoring in MRI to Detect Cardiac Ischemia; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS): Animal Models; Models for Screening Antiepileptic and Antiepileptogenic Therapy; Alertness Measures; Improved EEG/ICU/OR Interface; Medication Dispensing Monitor; Improving Magnetic Resonance Imaging to Evaluate the Central Nervous System of Critically-ill Neonates; Development of Neuronal Pluripotential Neuronal Stem Cells; Quantitative Tremor Measurement; Inducible Knockout Technology; Genome Scanning; Direct Gene Transfer; NATIONAL CENTER FOR RESEARCH RESOURCES (NCRR): General Software Tools for Biomedical Research; CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) - NATIONAL CENTER FOR HEALTH STATISTICS (NCHS): Electronic Death Registration System Prototype; NATIONAL IMMUNIZATION PROGRAM (NIP): Design a Multi-channel, Needleless Injector Device to Administer Vaccines; PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO): Distance Learning (DL) Support Technology. The SBIR Contract Solicitation PHS 97-1, including proposal forms, will be available electronically on or about September 6, 1996, through the NIH Home Page on the World Wide Web at: HTTP://WWW.NIH.GOV. A limited number of hard copies of the Solicitation will be available on or about September 13, 1996, from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. (0248)

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