National Cancer Institute, Research Contracts Branch, PSCS 6120 Executive Blvd., EPS/ROOM 634, Bethesda, Maryland 20892-7227

66 -- PLUS PEPTIDE SYNTHESIZER SOL RFQ70005-NS POC Patricia Haun, Contracting Officer, 301-402-4509. The National Cancer Institute (NCI) requires delivery and installation of a 9050 Plus Peptide Synthesizer from PerSeptive Biosystems, Inc., 500 Old Connecticut Path, Farmingham, MA 01701. The NCI Laboratory of Tumor Immunology and Biology develops methods of inducing the immune system to recognize and reject tumor cells bering tumor-associated antigens, and must synthesize large panels of different peptides and/or large amounts of individual peptides in performing this research. The Perseptive 9050 PLUS synthesizer will enable NCI to increase capabilities in three ways 1) Improvements in coupling chemistry to shorten the time required for synthesis (up to 3 peptides can be synthesized simultaneously). 2) Peptides can be produced in a wide range of synthesis scales with automatic adjustment of parameters such as flow rate and reagent consumption. 3) Synthesis of peptieds greater than 30 amino acids in lenth is facilitated. The equipment will enable NCI to link several sequences together to improve immunogenicity and delivery to cell, and will be driven by a dedicated computer workstation, utilize prepackaged reagents, and include a manual injection port and feedback monitoring. This notice of intent is not a request for competitive proposals. However, if any interested party believes that it can meet the above requirements, it may submit a statement of capabilities. Information furnished shall include sufficient detail to determine if the equipment meets the foregoing requirements, and must be received with 20 days of publication of this notice. See Note 22. (0305)

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