Contracts Management Branch, NICHD, National Institutes of Health, Executive Building, Suite 7A07, 6100 Executive Blvd MSC 7510, Bethesda, Maryland 20892-7510

A -- SUBCONTRACTING OPPORTUNITIES FOR STUDYING PERINATAL TRANSMISSION OF HIV-1 SOL N01-HD-3-3162A DUE 010397 POC Contact Mrs. Carol Nesel, 301/738-8337 Correction: This action originally published in the CBD is amended to delete all references to study #2 entitled: Herpes simplex virus (HSV) shedding and HIV plasma viral load in HIV-seropositive/HSV-seropositive women and HIV-seropositive/HSV-seronegative women. However, the National Institute of Child Health and Human Development (NICHD) continues to seek sources for subcontracting opportunities under an ongoing contract with Westat, Inc. Through this contract NICHD sponsors a network of clinical centers which participate in clinical trials of therapies to prevent mother to child transmission of HIV infection and to treat pediatric HIV disease. NICHD plans to further assess the critical factors responsible for perinatal transmission of HIV-1 by conducting the following study: (1) The influence of ovulatory phase on the detection of HIV-1 in the vaginocervical secretions from HIV seropositive women. It is the intent of NICHD and Westat to award additional subcontracts to qualified organizations to perform this research. Organizations interested in conducting this study should submit five copies of a statement of capabilities which must include the following: (a) evidence of an existing longitudinal co-hort of HIV-1 seropositive women (b) demonstrated ability to perform intensive substudies requiring weekly interviews and gynecologic examinations for eight weeks (c) demonstrated ability to collect, process, and ship cervicovaginal secretions according to current state of the art procedures, (d) a description of staff qualifications (include CVs of the proposed Principal Investigator (PI), description of HIV-related and non-HIV-related research experience (types and number of studies including drug trials, natural history studies, etc., total patient enrollment per study); and e) a description of the physical facilities where work is to be conducted. Capability statements (limited to 10 pages exclusive of CVs) should be submitted to Ms. Carol Nesel, Associate Director, Westat, Inc., 1650 Research Boulevard, Rockville, MD 20850. The deadline for submission is 2:00pm EST January 3, 1997. (0337)

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