DIRECTOR, USAMRAA, MCMR-AAA, BLDG 820, FORT DETRICK, FREDERICK MD 21702-5014

A -- REQUEST FOR PROPOSALS SOL CBD700-0000-0001 POC Contracting Officer Craig D. Lebo (301) 619-2036 (Site Code DAMD17) The Department of Defense is soliciting proposals to: (1) determine the feasibility of epidemiological studies in human subjects, including those thought to be near Kamisayah, Iraq during the first two weeks of March, 1991 and, (2) conduct animal stuies, designed to assess the possible long-term or delayed clinical effects of low level or subclinical exposures to chemical warfare agents. Low level exposures are defined as measurable exposures to chemical agents which are insufficient to cause acute sins or symptoms. The proposals should address defining appropriate design and methodological considerations as well as defining appropriate parameters for exposure and measurement of possible clinical effects of low-level nerve agent exposure. The focus of these proposals should be the assessment of possible health effects due to exposure to low levels of chemical warfare nerve agents, such as sarin. In addition, parmeters of particular interest include clinically significant behavioral, neurological, or electrophysiological sequelae to such exposures. For the feasibility of epidemiologic studies a determination should be made as to whether data are, or are likely to ecome, available and sufficient to estimate the likelihood that such exposures to the test chemicals have long-term clinical effects or delayed sequelae. For the animal studies proponents should have the capability to conduct pilot investigations with appropriate nerve agents and species. Proponents should also know that the results of these studies will become matters of public record. There is currently aproximnately $2.0M available for this effort and it is anticipated that at least two (2) awards for research projects will be made. Research projects are customarily in the two to four year duration. Proposals should be submitted in accordance with Broad Aency Announcement 95-1 copies of which are available by faxing a request to (301) 619-2937. Proposals should be sent to: Commander, U.S. Army Medical Research and Materiel Command, ATTN: MCMR-AAA, Fort Detrick, Frederick, MD 21702-5012. Proposals should be received NLT 19 February 1997. (0341)

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