Contracts Management Section, National Institute of Dental Research, NIH, 45 Center Drive, Room 4AN-44D, Bethesda, Maryland 20892.

A -- IMMUNE FUNCTION IN CHILDREN FOLLOWING RESTORATION OF CARIOUS LESIONS WITH DENTAL AMALGAM SOL RFP NIH-NIDR-11-97-5 POC Marilyn R. Zuckerman, Contracting Officer, (301) 594-5569. This is a notice of intent to issue RFP NIH-NIDR-11-97-5 on a sole-source basis to New England Research Institute (NERI), Watertown, Massachusetts 02172. The proposed three-year study will conduct a screen of immune function in children following restoration of carious lesions with dental amalgam. The study will be performed on the population of children enrolled in a clinical trial on the health effects of dental amalgam conducted through the New England/Forsyth Dental Center Children's Amalgam Trial Consortium. The screen will involve both functional and population assays of B-, T-, and NK- cell populations in a subset of children enrolled into each arm of the clinical trial. Negotiations will be conducted on a sole-source basis under authority of 41 U.S.C. 253(c)(1), as set forth in FAR 6.302-1. See Note 22. (0341)

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