National Cancer Institute, Research Contracts Branch, PSCS 6120 Executive Blvd., EPS/634 Bethesda, Maryland 20892-7227

B -- MODULATION OF DRUG RESISTANCE: EFFLUX PHENOTYPES IN CHILDHOOD LEUKEMIA SOL RFQ-70021-NS DUE 020597 POC Trish Haun, Contracting Officer, 301/402-4509. The National Cancer Institute (NCI) intends to enter into a three (3) year contract with the Children's National Medical Center (CNMC), Washington, DC, to provide services associated with a project entitled: "Modulation of Drug Resistance: Efflux Phenotypes in Childhood Leukemia." This study will provide insight into the biological mechanisms related to treatment failure. The incidence and prevalence of resistance proteins that pump chemotherapy out of leukemia cells will be evaluated by flow cytometry. This project will study how common these drug resistance proteins are in childhood leukemia, evaluate if their effect can be reversed and relate these findings to initial response to treatment, relapse, long-term relapse-free survival, and survival. The proposed work results from a grant which was awarded by the American Cancer Society (ACS) to Dr. S. Percy Ivy, formerly an Assistant Professor/Attending Physician, at CNMC. Dr. Ivy has recently accepted a full time position with the NCI and thisacquisition will provide a mechanism for conduct of the work proposed. Dr Ivy's participation and technical direction of this project is considered critical to the successful completion of the work, as she is the Principal Investigator for the ACS grant. In addition, the team and resources at CNMC, such as the Childrens Cancer Group (CCG) Reference Laboratory, specified in the grant application were also key factors in the peer review approval. This is not a request for competitive solicitation. Organizations who wish to respond to this notice must have their documentation at the following address no later than 2:30 PM EST on 02/05/97 to Trish Haun, 6120 Executive Boulevard, Room 634, Rockville, MD 20892-7227. No collect calls will be accepted. (0353)

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