EPA, ADP Placement Section (3803F), 401 M St. SW, Washington, DC 20460-0001

A -- EVALUATION OF EPIDEMIOLOGIC EVIDENCE FOR MAKING INFERENCES OF CANCER HAZARDS AND RISKS FOR EXPOSURE TO TRICHLORETHYLENE SOL D7E401 DUE 012997 POC Melissa Revely-Brown WEB: NOT AVAILABLE, http://www.epa.gov/oam/hpod. E-MAIL: CLICK HERE TO CONTACT THE CONTRACTING OFFICER, revely-brown.melissa@epamail.epa.gov. The U.S. Environmental Protection Agency (EPA) is issuing a request for proposal for services to which the Government intends to award a firm fixed price contract using the Simplified Acquisition Procedures of FAR Part 13. The EPA is FACNET certified. Any contractor/vendor able to meet requirement must demonstrate in writing by closing date. All responsible sources solicited may submit a bid, proposal, or quotation, which shall be considered. This notice is intended for competitive purposes. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive or negotiated procurement. The solicitation identifies the office where additional technical information can be obtained and you may E-mail the contracting officer at revely-brown.melissa@epamail.epa.gov for a copy of the solicitation. Please include the following: Company Name; Address; Phone Number; Business Class; and Email Address. All requests for the solicitation received by the closing date of this Notice will receive a copy of the statement of work. (The 202/260-1225 number listed is a fax number.) No phone calls accepted. All questions must be addressed in writing and will be answered in writing to all interested parties. SUBJECT: Evaluation of the Epidemiologic Evidence for Making Inferences of Cancer Hazards and Risks for Exposure to Trichloroethylene Background Trichloroethylene (TRI) is found in over 30% of Superfund sites, including several Department of Energy and Department of Defense sites. In the mid- 1980's, EPA evaluated the carcinogenicity of TRI (Health Assessment Document for Trichloroethylene, EPA/600/8-82/006F, 1985; Addendum, Draft, EPA/600/8-82-006FA, 1987). Risk-based standards and cleanup decisions were based on the cancer slope factor developed in the draft addendum and has been available on U.S. EPA's IRIS. The IRIS entry, however, was withdrawn in 1989 pending resolution of the classification as B2 (probably carcinogenic) or C (possibly carcinogenic). Additionally, EPA does not have a position on trichloroethylene's noncancer effects; an RfD and RfC have not been developed. Within the past five years, new research has been published on several aspects of trichloroethylene's toxicity. This research includes epidemiologic studies of trichloroethylene-exposed populations, pharmacokinetic models on trichloroethylene and it's metabolites, and proposed modes of action for kidney, liver, and lung toxicity/carcinogenicity. EPA's National Center for Environmental Assessment has committed to examining the non-cancer and cancer effects associated with trichloroethylene and its metabolites. With respect to the human evidence, several epidemiologic studies of carcinogenic effects and exposure to trichloroethylene in both the occupational setting and from groundwater contamination (environmental studies) have becomeavailable in the past several years. The International Agency for Research on Cancer (IARC, 1995) considered this epidemiologic evidence as "limited", leading to an overall classification for trichloroethylene of "2B, probably carcinogenic to humans." The American Council of Governmental Industrial Hygienists (ACGIH), alternatively, evaluated the occupational epidemiologic data and concluded that the evidence did not indicate a carcinogenic risk. ACGIH classified occupational trichloroethylene exposure as "A5, not carcinogenic to humans." The IARC evaluation is based upon a somewhat larger data base than that used by ACGIH. Additionally, IARC used a method to aggregate information across studies to support their conclusion, whereas, ACGIH did not. For a copy of the statement of work, please email your reques to revely-brown.melissa@epamail.epa.gov. Please include the following: Company Name; Address; Phone Number; Business Class; and Email Address. All requests for the solicitation received by the closing date of this Notice will receive a copy of the statement of work. (0007)

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