Family Health International P.O. Box 13950, Research Triangle Park, North Carolina, 27709

A -- CLINICAL TRIALS OF VACCINE AND NON-VACCINE INTERVENTIONS FOR R HIV PREVENTION IN DEVELOPING COUNTRIES THROUGH THE HIVNET SOL FHI/IMC/N01-AI-35173/SFP2AB DUE 050597 POC Nancy Lamson, (919) 544-6979 ext. 328 Family Health International (FHI), under Contract No. N01-AI-35173 with the Vaccine Trials and Epidemiology Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, is soliciting proposals from organizations for international sites capable of conducting clinical trials of vaccine and non-vaccine interventions for HIV prevention. Proposals are sought for sites to conduct randomized, controlled trials of chemical (microbicides) and physical barriers to sexual transmission of HIV, interventions to prevent perinatal transmission of HIV, behavioral interventions with HIV incidence as a primary outcome, preventive vaccine candidates, and sites to study the relationship between hormonal contraceptive use and HIV acquisition, and to evaluate other innovative approaches. Other innovative approaches, include, but are not limited to, STD prevention strategies for HIV control and micronutrients for the prevention of HIV. Sites may propose more than one type ofresearch. It is anticipated that six to nine cost-reimbursement, completion type subcontracts will be awarded for a period of five (5) years. The electronic version of SFP FHI/IMC/N01-AI-35173/SFP2AB will be available on or about February 3, 1997, through the Family Health International Homepage on the Internet at http://www.fhi.org. Once inside the FHI Homepage, click on "What's New", then click on "FHI/IMC/N01-AI-35173/SFP2AB Clinical Trials of Vaccine and Non-Vaccine Interventions for HIV Prevention in Developing Countries Through the HIVNET". All information required for the submission of an offer will be posted on the FHI Homepage. Responses to this SFP are tentatively set to be submitted on May 5, 1997. Any responsible offeror may submit a proposal which will be considered by FHI and the Government. This advertisement does not commit FHI and the Government to award a subcontract. Point of Contact: Nancy Lamson, Electronic Mail Address: NLamson@fhi.org Telephone: (919) 544-6979 ext. 328; Fax: (919) 544-0207 (0015)

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