DIRECTOR, USAMRAA, 820 CHANDLER ST, FORT DETRICK MD 21702-5014

A -- A -- PERSIAN GULF WAR ILLNESS RESEARCH SOL CBD700-0000-0001 POC Contracting Officer Craig D. Lebo (301) 619-2036 (Site Code DAMD17) The U.S. Army Medical Research and Acquisition Activity previously announced in the Commerce Business Daily the interest in obtaining proposals for the conduct of research in the area of Persian Gulf War Illnesses (see CBD Issue PSA #1738, dated December 10, 1996 and CBD Issue PSA #1761, dated January 14, 1997). These previous Department of Defense announcements, which solicited research proposals on four topics related to Persian Gulf War Illnesses are modified as indicated below with due dates as follows: (1) Determine the feasibility of epidemiological studies in human subjects, including those thought to be near Kamisayah, Iraq during the first two weeks of March, 1991 or (2) Conduct animal studies, designed to assess the possible long-term or delayed clinical effects of low level or subclinical exposures to chemical warfare agents. Additional details concerning these two topics are provided in the first announcement (CBD Issue PSA #1738, dated December 10, 1996). There is approximately $2.0M available for this effort and proposals will be considered from federal and nonfederal agencies. Proposals must be received NLT 4:00 p.m. EST, 19 February 1997. (3) Investigation of causal relationships between illnesses and symptoms among Gulf War veterans and possible exposures to hazardous material; chemical warfare agents; stress; potentially hazardous combinations of inoculations (i.e., anthrax and botulinum toxin) and investigational new drugs (i.e., pyridostigmine bromide) during military service in the Southwest Asia theater of operations during the Persian Gulf War. Approximately $9.5M is available only to principal investigators and institutions independent of the Federal Government in accordance with the provisions of the Byrd Amendment. Proposals must be received NLT 4:00 p.m. EST, 11 March 1997. (4) Studies of historical war syndromes, including investigation of factors which create a confluence of cognitive, emotional and physical factors to produce chronic, non-specific symptoms and physiological outcomes (e.g., neurologic, immunologic and endocrine responses). There is approximately $5M available for proposals from federal and nonfederal agencies. Proposals must be received NLT 4:00 p.m. EST, 30 April 1997. Large scale epidemiological studies must include provisions for scientific and public advisory committees as recommended by the Presidential Advisory Committee on Gulf War Veterans' Illnesses and Persian Gulf Veterans Coordinating Board. Research proposals are customarily in two to four year durations. Proposals should be submitted in accordance with Broad Agency Announcement 95-1 which is available on the internet. The web site is: http://www.usamraa.army.mil. Send proposals to: Commander, U.S. Army Medical Research and Materiel Command, ATTN: MCMR-AAA, Fort Detrick, MD 21702-5012. (0029)

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